Lactobacillus plantarum LP104 ameliorates hyperlipidemia induced by AMPK pathways in C57BL/6N mice fed high-fat diet

被引：45
|
作者：
Teng, Yue [1 ]
Wang, Yu [1 ]
Tian, Yuan [1 ]
Chen, Yi-ying [1 ]
Guan, Wu-yang [1 ]
Piao, Chun-hong [1 ,2 ,3 ,4 ]
Wang, Yu-hua [1 ,2 ,3 ,4 ]
机构：
[1] Jilin Agr Univ, Coll Food Sci & Engn, Changchun, Peoples R China
[2] Jilin Agr Univ, Jilin Prov Innovat Ctr Food Biol Manufacture, Changchun, Peoples R China
[3] Natl Proc Lab Soybean Ind & Technol, Changchun, Peoples R China
[4] Natl Engn Lab Wheat & Corn Deep Proc, Changchun, Peoples R China
来源：
JOURNAL OF FUNCTIONAL FOODS | 2020年 / 64卷
关键词：
Lactobacillus plantarum LP104; Hyperlipidemia; AMPK; Liver injury; LIVER-DISEASE; OXIDATIVE STRESS; GUT MICROBIOTA; POLYSACCHARIDES; METABOLISM; PROBIOTICS; EXTRACT; INJURY;
D O I：
10.1016/j.jff.2019.103665
中图分类号：
TS2 [食品工业];
学科分类号：
0832 ;
摘要：
Lactobacillus plantarum LP104 was isolated with excellent antioxidant properties from kimchi. In order to evaluate the role of LP104 in improving hyperlipidemia in high-fat-diet mice, C57BL/6N mice were randomly assigned into three groups treated with different diets: normal chow (Control), HFD, and HFD with L. plantarum LP104. After eight weeks, L. plantarum LP104 treatment significantly reduced HFD-induced body weight gain and the levels of serum or liver TC, TG, LDL, ALT, AST, LPS and TNF-alpha, and elevated liver HDL levels. The liver lipid accumulation was decreased in L. plantarum LP104 group. L. plantarum LP104 could activate the AMPK/Nrf2/CYP2E1 related pathway and regulate expressions of related proteins by using western blotting. Therefore, L. plantarum LP104 will improve hyperlipidemia, liver metabolic disorders, and liver oxidative stress response.
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页数：10
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