Lactobacillus plantarum LP104 ameliorates hyperlipidemia induced by AMPK pathways in C57BL/6N mice fed high-fat diet

Lactobacillus plantarum LP104 was isolated with excellent antioxidant properties from kimchi. In order to evaluate the role of LP104 in improving hyperlipidemia in high-fat-diet mice, C57BL/6N mice were randomly assigned into three groups treated with different diets: normal chow (Control), HFD, and HFD with L. plantarum LP104. After eight weeks, L. plantarum LP104 treatment significantly reduced HFD-induced body weight gain and the levels of serum or liver TC, TG, LDL, ALT, AST, LPS and TNF-alpha, and elevated liver HDL levels. The liver lipid accumulation was decreased in L. plantarum LP104 group. L. plantarum LP104 could activate the AMPK/Nrf2/CYP2E1 related pathway and regulate expressions of related proteins by using western blotting. Therefore, L. plantarum LP104 will improve hyperlipidemia, liver metabolic disorders, and liver oxidative stress response.