Synthesis of optically active aminooxy alcohols

被引：9

作者：

Buchalska, E ^{[1
]}

Plenkiewicz, J ^{[1
]}

机构：

[1] Warsaw Univ Technol, Dept Chem, PL-00664 Warsaw, Poland

来源：

JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC | 2001年 / 11卷 / 4-6期

关键词：

aminooxy alcohols; hydroxylamine derivatives; hydroxyisoxazolidine; secondary alcohols; lipase-catalyzed acetylation; enantiomers separation;

D O I：

10.1016/S1381-1177(00)00073-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Racemic secondary alcohols with an N-protected oxyamino function in the beta -position were prepared by a base-catalyzed epoxide ring opening with N-hydroxyphthalimide or acetone oxime. The enantiomers were separated with a good selectivity by a lipase-catalyzed acetylation of the racemates with vinyl acetate. The protecting group of the aminooxy alcohol was split off by a hydrochloric acid hydrolysis to yield the hydrochloride of one of the enantiomeric forms of the title compounds. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：255 / 263

页数：9

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