Recent advances in research on Crimean-Congo hemorrhagic fever

被引：52

作者：

Papa, Anna ^{[1
]}

Mirazimi, Ali ^{[2
,3
,4
]}

Koksal, Iftihar ^{[5
]}

Estrada-Pena, Augustin ^{[6
]}

Feldmann, Heinz ^{[7
]}

机构：

[1] Aristotle Univ Thessaloniki, Dept Microbiol, Thessaloniki 54124, Greece

[2] Swedish Inst Communicable Dis Control, SE-17182 Solna, Sweden

[3] Natl Vet Inst, SE-75651 Uppsala, Sweden

[4] Linkopings Univ, Dept Clin & Expt Med, SE-58183 Linkoping, Sweden

[5] Karadeniz Tech Univ, Fac Med, Dept Infect Dis, Trabzon, Turkey

[6] Univ Zaragoza, Dept Anim Pathol, Zaragoza, Spain

[7] NIAID, Virol Lab, Div Intramural Res, NIH, Hamilton, MT USA

来源：

JOURNAL OF CLINICAL VIROLOGY | 2015年 / 64卷

基金：

瑞典研究理事会;

关键词：

Crimean-Congo hemorrhagic fever; Ecology; Epidemiology; TICK-BORNE ENCEPHALITIS; NECROSIS-FACTOR-ALPHA; VIRAL LOAD; CIRCLE AMPLIFICATION; HYALOMMA-MARGINATUM; MOLECULAR-DETECTION; VIRUS-INFECTION; CLIMATE-CHANGE; RIBAVIRIN; INTERFERON;

D O I：

10.1016/j.jcv.2014.08.029

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Crimean-Congo hemorrhagic fever (CCHF) is an expanding tick-borne hemorrhagic disease with increasing human and animal health impact. Immense knowledge was gained over the past 10 years mainly due to advances in molecular biology, but also driven by an increased global interest in CCHFV as an emerging/re-emerging zoonotic pathogen. In the present article, we discuss the advances in research with focus on CCHF ecology, epidemiology, pathogenesis, diagnostics, prophylaxis and treatment. Despite tremendous achievements, future activities have to concentrate on the development of vaccines and antivirals/therapeutics to combat CCHF. Vector studies need to continue for better public and animal health preparedness and response. We conclude with a roadmap for future research priorities. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：137 / 143

页数：7

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