Reference ranges of fetal heart function using a Modified Myocardial Performance Index: a prospective multicentre, cross-sectional study

被引：13

作者：

Sun, Lijuan ^{[1
]}

Wang, Jingjing ^{[1
]}

Su, Xiaoting ^{[2
]}

Chen, Xinlin ^{[3
]}

Zhou, Yuqing ^{[4
]}

Zhang, Xiaoming ^{[5
]}

Lu, Hong ^{[6
]}

Niu, Jianmei ^{[7
,8
]}

Yu, Lan ^{[9
]}

Sun, Congxin ^{[10
]}

Zhang, Wenjun ^{[11
]}

Han, Jijing ^{[1
]}

Zhang, Lina ^{[1
]}

Wang, Zhenna ^{[2
]}

Chen, Peiwen ^{[3
]}

Chen, Tiantian ^{[4
]}

Hong, Hua ^{[5
]}

Zhou, Lulu ^{[6
]}

Ye, Baoying ^{[7
,8
]}

Guo, Wei ^{[9
,10
]}

Zhao, Wei ^{[10
]}

Zhang, Na ^{[1
]}

Li, Zhen ^{[1
]}

Zhao, Sheng ^{[3
]}

Wu, Qingqing ^{[1
]}

Tian, Jiawei ^{[12
]}

Jiang, Yuxin ^{[13
]}

机构：

[1] Capital Med Univ, Beijing Obstet & Gynecol Hosp, Dept Ultrasound, Beijing, Peoples R China

[2] Qingdao Women & Childrens Hosp, Dept Ultrasound, Qingdao, Shandong, Peoples R China

[3] Maternal & Child Hlth Hosp Hubei Prov, Dept Ultrasound, Wuhan, Hubei, Peoples R China

[4] Shanghai Changning Matern & Infant Hlth Hosp, Dept Ultrasound, Shanghai, Peoples R China

[5] Inner Mongolia Peoples Hosp, Dept Ultrasound, Hohhot, Inner Mongolia, Peoples R China

[6] Zhejiang Univ, Womens Hosp, Sch Med, Dept Ultrasound, Hangzhou, Zhejiang, Peoples R China

[7] Shanghai Jiao Tong Univ, Sch Med, Dept Ultrasound, Shanghai, Peoples R China

[8] Shanghai Jiao Tong Univ, Sch Med, Int Peace Matern & Child Hlth Hosp, Shanghai, Peoples R China

[9] Peoples Hosp Xinjiang Uygur Autonomous Reg, Dept Ultrasound, Xinjiang, Peoples R China

[10] Shijiazhuang Obstet & Gynecol Hosp, Dept Ultrasound, Shijiazhuang, Hebei, Peoples R China

[11] Hubei Univ Med, Dept Med Ultrasound, Taihe Hosp, Shiyan, Hubei, Peoples R China

[12] Harbin Med Univ, Affiliated Hosp 2, Dept Ultrasound, Harbin, Heilongjiang, Peoples R China

[13] Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Ultrasound, Beijing, Peoples R China

来源：

BMJ OPEN | 2021年 / 11卷 / 07期

关键词：

echocardiography; heart failure; cardiology; ultrasonography; prenatal diagnosis; fetal medicine; DEFINING NORMAL VALUES; MOD-MPI SYSTEM; CARDIAC-FUNCTION; 3RD TRIMESTERS; DOPPLER; 2ND;

D O I：

10.1136/bmjopen-2021-049640

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objectives The primary aim of this study was to establish the normal reference ranges of the fetal left ventricular (LV) Modified Myocardial Performance Index (Mod-MPI). A secondary aim was to evaluate the agreement between manual and automatic measurements for fetal Mod-MPI. Design A prospective, multicentre, cross-sectional study. Participants Normal singleton pregnancies. Methods The LV functions of normal singleton pregnancies were assessed in nine centres covering eight provinces in China using unified ultrasound protocols and settings and standardised measurements by pulsed Doppler at 20-24, 28-32 and 34-38 weeks of gestation. The isovolumetric relaxation time (IRT), isovolumetric contraction time, ejection time (ET) and Mod-MPI were measured both automatically and manually. Results This cross-sectional study included 2081 fetuses, and there was a linear correlation between gestational age (GA) and Mod-MPI (0.416+0.001xGA (weeks), p<0.001, r(2)=0.013), IRT (36.201+0.162x GA (weeks), p<0.001, r(2)=0.021) and ET (171.418-0.078*GA (weeks), p<0.001, r(2)=0.002). This finding was verified using longitudinal data in a subgroup of 610 women. The agreement between the manual and automated measurements for Mod-MPI was good. Conclusions We constructed normal reference values of fetal LV Mod-MPI. Automatic measurement can be considered for ease of measurement in view of the good agreement between the automatic and manual values.

引用

页数：10

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