Synthesis and cytotoxic activity of different open indolocarbazole alkaloid analogues

被引：26

作者：

Caballero, E ^{[1
]}

Adeva, M

Calderón, S

Sahagún, H

Tomé, F

Medarde, M

Fernández, JL

López-Lázaro, M

Ayuso, MJ

机构：

[1] Fac Farm, Lab Quim Organ & Farmaceut, Salamanca 37007, Spain

[2] Inst Biomar SA, Leon 24231, Spain

[3] Fac Farm, Dept Farmacol, Seville, Spain

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2003年 / 11卷 / 16期

关键词：

D O I：

10.1016/S0968-0896(03)00308-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

An array of 4-(aryl or indolyl)pyrrolo[3,4-c]carbazole-1,3-diones (open analogues of indolocarbazole alkaloids), 10-(aryl or indolyl)pyrrolo [3,4-b]carbazole-1,3-diones, and different derivatives have been prepared using a Diels-Alder plus Fischer indolization approach and tested as cytotoxic agents. Some representative compounds display interesting cytotoxic profiles. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：3413 / 3421

页数：9

共 36 条

[1] New 7-aryl analogues of anthracyclines:: Synthesis and cytotoxic activity of (±)-7-(3,4,5-trimethoxyphenyl)-7-deoxyidarubicinone [J].

Acosta, JC ;

Caballero, E ;

Grávalos, DG ;

Medarde, M ;

Sahagún, H ;

Stoodley, RJ ;

Tomé, F .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1997, 7 (23) :2955-2958

[2]

Adeva M, 2000, SYNLETT, P832

[3] Diels-Alder reactivity of 1-alkoxyphenyl-3-trialkylsiloxy-1,3-dienes [J].

Adeva, M ;

Caballero, E ;

Garcia, F ;

Medarde, M ;

Sahagun, H ;

Tome, F .

TETRAHEDRON LETTERS, 1997, 38 (39) :6893-6896

[4] Open analogues of arcyriaflavin A.: Synthesis through Diels-Alder reaction between maleimides and 1-aryl-3-tert-butyldimethylsiloxy-1,3-butadienes [J].

Adeva, M ;

Sahagún, H ;

Caballero, E ;

de Clairac, RPL ;

Medarde, M ;

Tomé, F .

JOURNAL OF ORGANIC CHEMISTRY, 2000, 65 (11) :3387-3394

[5]

Akinaga S, 2000, ANTI-CANCER DRUG DES, V15, P43

[6]

[Anonymous], 1993, STUDIES NATURAL PROD

[7] EUDISTOMIN-U AND ISOEUDISTOMIN U, NEW ALKALOIDS FROM THE CARIBBEAN ASCIDIAN LISSOCLINUM-FRAGILE [J].

BADRE, A ;

BOULANGER, A ;

ABOUMANSOUR, E ;

BANAIGS, B ;

COMBAUT, G ;

FRANCISCO, C .

JOURNAL OF NATURAL PRODUCTS, 1994, 57 (04) :528-533

[8]

Bergman J., 1988, STUDIES NATURAL PR A, V1, P3

[9]

BROKA CA, 1996, Patent No. 695755

[10] Synthesis and cytotoxic activity of phenyl-hexahydropyrrolo[3,4-c]carbazoles [J].

Caballero, E ;

Garcia, F ;

Gravalos, DG ;

Medarde, M ;

Sahagun, H ;

Tome, F .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1996, 6 (20) :2459-2462

← 1 2 3 4 →