Analysis of amphetamine-type substances by capillary zone electrophoresis using capacitively coupled contactless conductivity detection

被引：22

作者：

Epple, Rochelle ^{[1
]}

Blanes, Lucas ^{[1
]}

Beavis, Alison ^{[1
]}

Roux, Claude ^{[1
]}

Doble, Philip ^{[1
]}

机构：

[1] Univ Technol Sydney, Ctr Forens Sci, Dept Chem & Forens Sci, Sydney, NSW 2007, Australia

来源：

ELECTROPHORESIS | 2010年 / 31卷 / 15期

关键词：

Amphetamines; Capacitively coupled contactless conductivity detection; CE; Ecstasy; Methamphetamine; MICROCHIP ELECTROPHORESIS; SEPARATION; CHROMATOGRAPHY; CYCLODEXTRINS; DRUGS;

D O I：

10.1002/elps.201000128

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

CE with capacitively coupled contactless conductivity detection ((CD)-D-4) was employed for the separation and detection of seven amphetamine analogues as well as amphetamine, dextroamphetamine, methamphetamine and 3,4-methylenedioxymethamphetamine. The separation electrolyte was 30 mM hydroxypropyl-beta-cyclodextrin (HP beta CD) in a 75 mM acetic acid + 25 mM sodium acetate buffer adjusted to pH 4.55. Conductivity detection was compared with UV detection using this same electrolyte. Average detection limits for (CD)-D-4 and UV were 1.3 and 1.0 ppm, respectively. The effects of HP beta CD concentration and BGE composition on the selectivity of the separation were also investigated. An illicit, street-grade sample of 3,4-methylenedioxymethamphetamine (Ecstasy) and a prescription dextroamphetamine tablet were also analysed.

引用

页码：2608 / 2613

页数：6

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