ANALYSIS OF CLINICAL RISK FACTORS FOR PREMATURE AND LATE-ONSET CORONARY HEART DISEASE

Objective: To explore the differences of risk factors between premature (PCHD) and late-onset coronary heart disease (CHD), and provide valuable references for prevention and treatments of PCHD. Methods: In total, 534 coronary heart disease patients from January 2015 to June 2017 in our hospital were enrolled in this study, and these patients were divided into PCHD and control (late-onset CHD) groups according to CHD onset age. These patients were followed-up for 24 months, and both general and clinical laboratory data of the two groups were recorded. Both single-factor and COX regression analyses were used to screen the risk factors and their differences between both groups. Results: Single-factor analysis showed that obesity, smoking history, CHD family history, and the levels of total cholesterol, triglyceride and haemoglobin (HGB) in the premature group were significantly higher than those in control group (P<0.05). The age and hypertension in premature group was significantly lower than those in the control group (P<0.05). COX regression analysis results in the premature group showed that obesity, hypertension, smoking history, CHD family history, total cholesterol and haemoglobin levels were independent risk factors. The COX regression analysis results in the control group demonstrated that hypertension, smoking history, drinking history, CHD family history and total cholesterol were independent risk factors. There were some differences in risk factors between premature and control groups. Conclusion: For PCHD patients, more targeted interventions should focus on high-risk factors such as obesity, hypertension, CHD family history, in order to improve PCHD outcomes.