Dendrites of Neocortical Pyramidal Neurons: The Key to Understand Intellectual Disability

被引：4

作者：

Granato, Alberto ^{[1
]}

Merighi, Adalberto ^{[1
]}

机构：

[1] Univ Turin, Dept Vet Sci, Largo Paolo Braccini 2, I-10095 Grugliasco, TO, Italy

来源：

CELLULAR AND MOLECULAR NEUROBIOLOGY | 2022年 / 42卷 / 01期

关键词：

Cerebral cortex; Down syndrome; Fetal alcohol; Calcium; Dendritic spike; Apical dendrite; SPINE DENSITY; CORTICAL INTERNEURONS; SYNAPTIC INTEGRATION; CELLULAR MECHANISM; APICAL DENDRITES; NMDA RECEPTOR; MURINE MODELS; DOWN-SYNDROME; RAT; ALCOHOL;

D O I：

10.1007/s10571-021-01123-1

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Pyramidal neurons (PNs) are the most abundant cells of the neocortex and display a vast dendritic tree, divided into basal and apical compartments. Morphological and functional anomalies of PN dendrites are at the basis of virtually all neurological and mental disorders, including intellectual disability. Here, we provide evidence that the cognitive deficits observed in different types of intellectual disability might be sustained by different parts of the PN dendritic tree, or by a dysregulation of their interaction.

引用

页码：147 / 153

页数：7

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