Characterization of a Novel HIV-1 Second-Generation Recombinant Form in Men Who Have Sex with Men in Beijing, China

被引：0
作者：
Wang, Chen [1 ]
Wang, Yan [1 ]
Kong, Desheng [1 ]
Xin, Ruolei [2 ]
Xu, Weisi [1 ]
Feng, Yi [1 ]
Shao, Yiming [1 ]
Ma, Liying [1 ]
机构：
[1] Chinese Ctr Dis Control & Prevent, Collaborat Innovat Ctr Diag & Treatment Infect Di, State Key Lab Infect Dis Prevent & Control, Div Virol & Immunol,Natl Ctr AIDS STD Control & P, 155 Changbai Rd, Beijing 102206, Peoples R China
[2] Beijing Ctr Dis Prevent & Control, Beijing, Peoples R China
来源：
AIDS RESEARCH AND HUMAN RETROVIRUSES | 2017年 / 33卷 / 11期
基金：
中国国家自然科学基金;
关键词：
HIV-1; recombinant; MSM; tropic; IDENTIFICATION; ORIGIN;
D O I：
10.1089/aid.2017.0143
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Cocirculation of multiple subtypes in the same population contributes significantly to the emergence of recombinant viruses. BJ2015EU19, a novel CCR5-tropic human immunodeficiency virus (HIV)-1, second-generation recombinant virus, was isolated from a man who has sex with men in Beijing, China. Phylogenetic analysis of the near full-length genome showed that BJ2015EU19 consisted of seven fragments from CRF01_AE and CRF07_BC. There were six recombinant breakpoints in the pol, vpu, env, and nef genes of BJ2015EU19, which were different from the other circulating recombinant forms and unique recombinant forms (URFs). The new emergence of the URF increases the complexity of the HIV epidemic in the Chinese homosexual group, and the ongoing generation of recombinant viruses may provide an important basis for future analysis of the recombination mechanism of HIV-1.
引用
收藏
页码：1175 / 1179
页数：5
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