Applications of catalytic asymmetric sulfide oxidations to the syntheses of biologically active sulfoxides

被引：418

作者：

Legros, J ^{[1
]}

Dehli, JR ^{[1
]}

Bolm, C ^{[1
]}

机构：

[1] Rhein Westfal TH Aachen, Inst Organ Chem, D-52056 Aachen, Germany

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2005年 / 347卷 / 01期

关键词：

asymmetric catalysis; chiral sulfoxides; drugs; lansoprazole; omeprazole; oxidation;

D O I：

10.1002/adsc.200404206

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Optically active sulfoxides are important compounds for medicinal and pharmaceutical chemistry. Driven by the increasing demand for efficient, selective and environmentally friendly industrial processes, several catalytic methodologies have been developed in recent years for the stereoselective oxidation of sulfides for the preparation of biologically active sulfoxides. Both small-scale approaches to the problem as well as some large-scale applications that are already in industrial use are described in this review.

引用

页码：19 / 31

页数：13

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