Light-sensitive intelligent drug delivery systems of coumarin-modified mesoporous bioactive glass

被引：80

作者：

Lin, H. -M. ^{[1
,2
]}

Wang, W. -K. ^{[1
]}

Hsiung, P. -A. ^{[2
]}

Shyu, S. -G. ^{[3
]}

机构：

[1] Natl Taiwan Ocean Univ, Inst Biosci & Biotechnol, Chilung 20224, Taiwan

[2] Natl Taiwan Ocean Univ, Dept Life Sci, Chilung 20224, Taiwan

[3] Acad Sinica, Inst Chem, Taipei 11529, Taiwan

来源：

ACTA BIOMATERIALIA | 2010年 / 6卷 / 08期

关键词：

Mesoporous bioactive glass; Photo-controlled; Drug delivery system; Light-sensitive intelligent; IN-VITRO BIOACTIVITY; GUEST MOLECULES; RELEASE; SILICA; NANOPARTICLES; SCAFFOLDS; HYDROGELS; CEMENTS; MCM-41;

D O I：

10.1016/j.actbio.2010.02.014

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Functionalized mesoporous bioactive glasses (MBG) with photoactive coumarin demonstrates photo-responsive dimerization resulting in reversible gate operation Coumarin-modified MBG was used as a drug delivery carrier to investigate drug storage/release characteristics using phenanthrene as a model drug Irradiation with UV light (>310 nm) induced photo-dimerization of the coumarin-modified MBG, which led to the pores' closing with cyclobutane dimers and trapping of the guest phenanthrene in the mesopores However, irradiating the dimerized-coumarin-modified MBG with shorter wavelength UV light (similar to 250 nm) regenerates the coumarin monomer derivative by the photo-cleavage of cyclobutane chillers, such that trapped guest molecules are released from the mesopores The structural, morphological, textural and optical properties are well characterized by X-ray diffraction, transmission electron microscopy, N-2 adsorption/desorption, and UV-visible spectroscopy The results reveal that the MBG exhibits the typical ordered characteristics of the hexagonal mesostructure The system demonstrates great potential in light-sensitive intelligent drug delivery systems and disease therapy fields. Crown Copyright (C) 2010 Published by Elsevier Ltd on behalf of Acta Materialia Inc All rights reserved

引用

页码：3256 / 3263

页数：8

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