Genetics of hypertension: The adducin paradigm

被引：18
作者：
Bianchi, G
Tripodi, G
机构：
[1] Univ Vita & Salute, Osped San Raffaele, Div Nefrol Dialisi & Ipertens, Chair Nephrol, I-20132 Milan, Italy
[2] Univ Vita & Salute, Osped San Raffaele, Div Nefrol Dialisi & Ipertens, Sch Nephrol, I-20132 Milan, Italy
来源：
NA,K-ATPASE AND RELATED CATION PUMPS: STRUCTURE, FUNCTION, AND REGULATORY MECHANISMS | 2003年 / 986卷
关键词：
adducin; genetics; hypertension; Na-K pump; endocytosis; tubular renal reabsorption;
D O I：
10.1111/j.1749-6632.2003.tb07280.x
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The following were investigated: (1) how we became interested in studying adducin genes and what we know about adducin; (2) studies in animals and humans supporting the role of adducin polymorphisms in hypertension, including some methodological problems related to the dissection of the role of a given genetic molecular mechanism in a complex multifactorial polygenic disease like hypertension; (3) biochemical mechanisms underlying the effect of adducin and its interaction with the Na-K pump; and (4) future directions.
引用
收藏
页码：660 / 668
页数：9
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