IMPROVE-IT and genetics reaffirm the causal role of LDL in Cardiovascular Disease Discussion

被引：23
作者：
Catapano, Alberico L. [1 ,2 ]
Ference, Brian A. [3 ]
机构：
[1] Univ Milan, Dept Pharmacol & Biomol Sci, I-20133 Milan, Italy
[2] IRCCS Multimed, I-20133 Milan, Italy
[3] Wayne State Univ, Sch Med UHC, Div Cardiovasc Med, Detroit, MI 48202 USA
来源：
ATHEROSCLEROSIS | 2015年 / 241卷 / 02期
关键词：
CORONARY-HEART-DISEASE; DENSITY-LIPOPROTEIN CHOLESTEROL; MENDELIAN RANDOMIZATION; NPC1L1; EZETIMIBE; EFFICACY; TRIALS; RISK; PARTICIPANTS; METAANALYSIS;
D O I：
10.1016/j.atherosclerosis.2015.06.008
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
引用
收藏
页码：498 / 501
页数：4
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共 15 条
  • [1] Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170 000 participants in 26 randomised trials
    Baigent, C.
    Blackwell, L.
    Emberson, J.
    Holland, L. E.
    Reith, C.
    Bhala, N.
    Peto, R.
    Barnes, E. H.
    Keech, A.
    Simes, J.
    Collins, R.
    [J]. LANCET, 2010, 376 (9753) : 1670 - 1681
  • [2] Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statins
    Baigent, C
    Keech, A
    Kearney, PM
    Blackwell, L
    Buck, G
    Pollicino, C
    Kirby, A
    Sourjina, T
    Peto, R
    Collins, R
    Simes, J
    [J]. LANCET, 2005, 366 (9493) : 1267 - 1278
  • [3] Multiple rare variants in NPC1L1 associated with reduced sterol absorption and plasma low-density lipoprotein levels
    Cohen, JC
    Pertsemlidis, A
    Fahmi, S
    Esmail, S
    Vega, GL
    Grundy, SM
    Hobbs, HH
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (06) : 1810 - 1815
  • [4] Large-scale association analysis identifies new risk loci for coronary artery disease
    Deloukas, Panos
    Kanoni, Stavroula
    Willenborg, Christina
    Farrall, Martin
    Assimes, Themistocles L.
    Thompson, John R.
    Ingelsson, Erik
    Saleheen, Danish
    Erdmann, Jeanette
    Goldstein, Benjamin A.
    Stirrups, Kathleen
    Koenig, Inke R.
    Cazier, Jean-Baptiste
    Johansson, Asa
    Hall, Alistair S.
    Lee, Jong-Young
    Willer, Cristen J.
    Chambers, John C.
    Esko, Tonu
    Folkersen, Lasse
    Goel, Anuj
    Grundberg, Elin
    Havulinna, Aki S.
    Ho, Weang K.
    Hopewell, Jemma C.
    Eriksson, Niclas
    Kleber, Marcus E.
    Kristiansson, Kati
    Lundmark, Per
    Lyytikainen, Leo-Pekka
    Rafelt, Suzanne
    Shungin, Dmitry
    Strawbridge, Rona J.
    Thorleifsson, Gudmar
    Tikkanen, Emmi
    Van Zuydam, Natalie
    Voight, Benjamin F.
    Waite, Lindsay L.
    Zhang, Weihua
    Ziegler, Andreas
    Absher, Devin
    Altshuler, David
    Balmforth, Anthony J.
    Barroso, Ines
    Braund, Peter S.
    Burgdorf, Christof
    Claudi-Boehm, Simone
    Cox, David
    Dimitriou, Maria
    Do, Ron
    [J]. NATURE GENETICS, 2013, 45 (01) : 25 - U52
  • [5] Effect of Naturally Random Allocation to Lower Low-Density Lipoprotein Cholesterol on the Risk of Coronary Heart Disease Mediated by Polymorphisms in NPC1L1, HMGCR, or Both
    Ference, Brian A.
    Majeed, Faisal
    Penumetcha, Raju
    Flack, John M.
    Brook, Robert D.
    [J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2015, 65 (15) : 1552 - 1561
  • [6] Effect of Long-Term Exposure to Lower Low-Density Lipoprotein Cholesterol Beginning Early in Life on the Risk of Coronary Heart Disease A Mendelian Randomization Analysis
    Ference, Brian A.
    Yoo, Wonsuk
    Alesh, Issa
    Mahajan, Nitin
    Mirowska, Karolina K.
    Mewada, Abhishek
    Kahn, Joel
    Afonso, Luis
    Williams, Kim Allan, Sr.
    Flack, John M.
    [J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2012, 60 (25) : 2631 - 2639
  • [7] The target of ezetimibe is Niemann-Pick Cl-Like 1 (NPC1L1)
    Garcia-Calvo, M
    Lisnock, JM
    Bull, HG
    Hawes, BE
    Burnett, DA
    Braun, MP
    Crona, JH
    Davis, HR
    Dean, DC
    Detmers, PA
    Graziano, MP
    Hughes, M
    MacIntyre, DE
    Ogawa, A
    O'Neill, KA
    Iyer, SPN
    Shevell, DE
    Smith, MM
    Tang, YS
    Makarewicz, AM
    Ujjainwalla, F
    Altmann, SW
    Chapman, KT
    Thornberry, NA
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (23) : 8132 - 8137
  • [8] Simvastatin with or without ezetimibe in familial hypercholesterolemia
    Kastelein, John J. P.
    Akdim, Fatima
    Stroes, Erik S. G.
    Zwinderman, Aeilko H.
    Bots, Michiel L.
    Stalenhoef, Anton F. H.
    Visseren, Frank L. J.
    Sijbrands, Eric J. G.
    Trip, Mieke D.
    Stein, Evan A.
    Gaudet, Daniel
    Duivenvoorden, Raphael
    Veltri, Enrico P.
    Marais, A. David
    de Groot, Eric
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2008, 358 (14) : 1431 - 1443
  • [9] Mendelian randomization: Using genes as instruments for making causal inferences in epidemiology
    Lawlor, Debbie A.
    Harbord, Roger M.
    Sterne, Jonathan A. C.
    Timpson, Nic
    Smith, George Davey
    [J]. STATISTICS IN MEDICINE, 2008, 27 (08) : 1133 - 1163
  • [10] Lipid-altering efficacy of ezetimibe plus statin and statin monotherapy and identification of factors associated with treatment response: A pooled analysis of over 21,000 subjects from 27 clinical trials
    Morrone, Doralisa
    Weintraub, William S.
    Toth, Peter P.
    Hanson, Mary E.
    Lowe, Robert S.
    Lin, Jianxin
    Shah, Arvind K.
    Tershakovec, Andrew M.
    [J]. ATHEROSCLEROSIS, 2012, 223 (02) : 251 - 261
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