SLE redefined on the basis of molecular pathways

被引：6

作者：

Barturen, Guillermo ^{[1
]}

Alarcon-Riquelme, Marta E. ^{[1
,2
]}

机构：

[1] Univ Granada, Pfizer, Andalusian Govt Ctr Genom & Oncol Res GENYO, PTS, Av Ilustrac 114, Granada 18016, Spain

[2] Karolinska Inst, Inst Environm Med, Unit Inflammatory Chron Dis, S-17777 Solna, Sweden

来源：

BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY | 2017年 / 31卷 / 03期

关键词：

Interferonopathies; Transcriptome; Epigenome; Genome-wide association studies; Human leukocyte antigens; Aicardi-Goutieres syndrome; C1q deficiency; TREX1; Neuropsychiatric SLE; Omics; SYSTEMIC-LUPUS-ERYTHEMATOSUS; GENOME-WIDE ASSOCIATION; GENE-EXPRESSION SIGNATURE; NAIVE CD4+T CELLS; DNA METHYLATION; RHEUMATOID-ARTHRITIS; AUTOIMMUNE-DISEASE; T-CELLS; SJOGRENS-SYNDROME; SYNOVIAL TISSUE;

D O I：

10.1016/j.berh.2017.09.006

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The implementation of precision medicine requires the recruiting of patients in statistically enough numbers, the possibility of obtaining enough materials, and the integration of data from various platforms, which are all real limitations. These types of studies have been performed extensively in cancer but barely on systemic lupus erythematosus (SLE) or other rheumatic diseases. To consider the practical use of the information obtained from such studies, we have to take into account the best biological fluid to use, the ease to perform the analysis in clinical practice, and its relevance to clinical practice. Here we review the most relevant studies that have performed analyses that attempt to classify or stratify SLE. We focus on two types of studies: those that stratify individuals diagnosed with SLE and those that compare SLE with other autoimmune diseases, defining differences and similarities that may be clinically relevant in the future. (C) 2017 Elsevier Ltd. All rights reserved.

引用

页码：291 / 305

页数：15

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