FACTORS AFFECTING EFFICACY OF GASTROESOPHAGEAL REFLUX DISEASE TREATMENT WITH PROTON PUMP INHIBITORS

被引：0

作者：

Lazebnik, L. B. ^{[1
]}

Bordin, D. S. ^{[1
]}

Masharova, A. A. ^{[1
]}

Firsova, L. D. ^{[1
]}

Silvestrova, S. Yu. ^{[1
]}

机构：

[1] Cent Sci Res Inst Gastroenterol, Moscow 111123, Russia

来源：

TERAPEVTICHESKII ARKHIV | 2012年 / 84卷 / 02期

关键词：

gastroesophageal reflux disease; quality of life; mental status; PPIs pharmacokinetics; SYMPTOMS; THERAPY; PATIENT;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Aim. The aim of the study was to determine causes of proton pump inhibitors. (PPIs) inefficacy in some patients suffering from gastroesophageal reflux disease (GERD). Material and methods. In our study of 154 GERD patients, 50 received omeprazole. 51 - lansoprazole and 53 - pantoprazole in a standard daily dose. GERD symptoms (heartburn and regurgitation) were scored by Likert scale: the patients' quality of life (SF-36) and their mental status (SMALL) were examined. Upper gastrointestinal endoscopy. 24-h intraesophageal pH monitoring, esophageal manometry and pharmacokinetic study were performed. Results. The treatment with a standard dose of PPIs was ineffective in 21 (13.6%) patients. Causes of PPIs inefficacy in 4.5% patients were rapid PPI metabolism and in 9.1% - "driving gear" of symptoms formation related with psychic dysadaptation.

引用

页码：16 / 21

页数：6

共 50 条

[1] Efficacy and Safety of Proton Pump Inhibitors in the Management of Pediatric Gastroesophageal Reflux Disease
Tjon, James A.
Pe, Michael
Soscia, Joanna
Mahant, Sanjay
PHARMACOTHERAPY, 2013, 33 (09): : 956 - 971
[2] Efficacy of Proton-Pump Inhibitors in Children With Gastroesophageal Reflux Disease: A Systematic Review
van der Pol, Rachel J.
Smits, Marije J.
van Wijk, Michiel P.
Omari, Taher I.
Tabbers, Merit M.
Benninga, Marc A.
PEDIATRICS, 2011, 127 (05) : 925 - 935
[3] Efficacy of mosapride plus proton pump inhibitors for treatment of gastroesophageal reflux disease: A systematic review
Liu, Qing
Feng, Chen-Chen
Wang, Er-Man
Yan, Xiu-Juan
Chen, Sheng-Liang
WORLD JOURNAL OF GASTROENTEROLOGY, 2013, 19 (47) : 9111 - 9118
[4] Efficacy of mosapride plus proton pump inhibitors for treatment of gastroesophageal reflux disease: A systematic review
Qing Liu
Chen-Chen Feng
Er-Man Wang
Xiu-Juan Yan
Sheng-Liang Chen
World Journal of Gastroenterology, 2013, (47) : 9111 - 9118
[5] Effects of Proton Pump Inhibitors on the Gastrointestinal Microbiota in Gastroesophageal Reflux Disease
Shi, Yi-Chao
Cai, Shun-Tian
Tian, Ya-Ping
Zhao, Hui-Jun
Zhang, Yan-Bing
Chen, Jing
Ren, Rong-Rong
Luo, Xi
Peng, Li-Hua
Sun, Gang
Yang, Yun-Sheng
GENOMICS PROTEOMICS & BIOINFORMATICS, 2019, 17 (01) : 52 - 63
[6] Prevalence of bile reflux in gastroesophageal reflux disease patients not responsive to proton pump inhibitors
Monaco, Luigi
Brillantino, Antonio
Torelli, Francesco
Schettino, Michele
Izzo, Giuseppe
Cosenza, Angelo
Di Martino, Natale
WORLD JOURNAL OF GASTROENTEROLOGY, 2009, 15 (03) : 334 - 338
[7] Effectiveness and Safety of Proton Pump Inhibitors in Infantile Gastroesophageal Reflux Disease
Higginbotham, Tanner W.
ANNALS OF PHARMACOTHERAPY, 2010, 44 (03) : 572 - 576
[8] Positive predictors for gastroesophageal reflux disease and the therapeutic response to proton- pump inhibitors
Becker, Valentin
Grotz, Stefan
Schlag, Christoph
Nennstiel, Simon
Beitz, Analena
Haller, Bernhard
Schmid, Roland M.
Meining, Alexander
Bajbouj, Monther
WORLD JOURNAL OF GASTROENTEROLOGY, 2014, 20 (14) : 4017 - 4024
[9] Factors Affecting the Association of Proton Pump Inhibitors and Capecitabine Efficacy in Advanced Gastroesophageal Cancer
Hussaarts, Koen G. A. M.
van Leeuwen, Roelof W. F.
Mathijssen, Ron H. J.
JAMA ONCOLOGY, 2018, 4 (02) : 263 - 264
[10] Proton Pump Inhibitors in Gastroesophageal Reflux Disease: Friend or Foe
Gyawali C.P.
Current Gastroenterology Reports, 2017, 19 (9)

← 1 2 3 4 5 →