Interaction of Age at Diagnosis with Transcriptional Profiling in Papillary Thyroid Cancer

被引：19

作者：

Hsu, Yi-Chiung ^{[1
,2
]}

Liu, Chien-Liang ^{[3
,4
,5
]}

Yang, Po-Sheng ^{[3
,4
,6
,7
]}

Tsai, Chung-Hsin ^{[3
,4
,5
]}

Lee, Jie-Jen ^{[3
,4
,5
,6
,7
]}

Cheng, Shih-Ping ^{[3
,4
,6
,7
]}

机构：

[1] Natl Cent Univ, Dept Biomed Sci & Engn, Taoyuan, Taiwan

[2] Acad Sinica, Inst Stat Sci, Taipei, Taiwan

[3] MacKay Mem Hosp, Dept Surg, 92 Chung Shan North Rd,Sect 2, Taipei 10449, Taiwan

[4] Mackay Med Coll, 92 Chung Shan North Rd,Sect 2, Taipei 10449, Taiwan

[5] Mackay Jr Coll Med Nursing & Management, Taipei, Taiwan

[6] Taipei Med Univ, Dept Pharmacol, Taipei, Taiwan

[7] Taipei Med Univ, Grad Inst Med Sci, Taipei, Taiwan

来源：

WORLD JOURNAL OF SURGERY | 2016年 / 40卷 / 12期

关键词：

V600E MUTATION; CARCINOMA; EXPRESSION; RECURRENCE; BRAF; EPIDEMIOLOGY; SURVEILLANCE; METABOLISM; SURVIVAL; CELLS;

D O I：

10.1007/s00268-016-3625-8

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Age is an important prognostic factor for papillary thyroid cancer (PTC). However, little is known about why advanced age is associated with poor prognosis. The study investigated the changes in transcriptional profiling related to age. RNA sequencing data of PTC samples were retrieved from The Cancer Genome Atlas data portal. Spearman's correlation was used to test the association between age and gene expression. Correlation in the same direction to disease severity was considered functionally relevant. Functional enrichment analysis and pathway annotations were performed. There was no correlation between age and thyroid-specific genes, except for a weak, negative association between age and TSHR expression. Among 272 genes with a positive association between gene expression and age, the most prominent alteration was metabolic pathways, particularly glycolysis. Among 482 genes with a negative association between gene expression and age, the most enriched biological process was immune-related functions, particularly natural killer cell-mediated cytotoxicity. Our analysis characterized the age-associated molecular landscape in PTC. Metabolic alterations and immune dysregulation are probable mechanisms involving in worse prognosis in older patients with PTC.

引用

页码：2922 / 2929

页数：8

共 39 条

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