Finding a sirtuin truth in Huntington's disease

被引：15
作者：
La Spada, Albert R. [1 ,2 ,3 ,4 ]
机构：
[1] Univ Calif San Diego, Dept Pediat, Div Biol Sci, La Jolla, CA 92093 USA
[2] Univ Calif San Diego, Dept Cellular & Mol Med, Div Biol Sci, La Jolla, CA 92093 USA
[3] Univ Calif San Diego, Dept Neurosci, Div Biol Sci, La Jolla, CA 92093 USA
[4] Univ Calif San Diego, Inst Genom Med, La Jolla, CA 92093 USA
来源：
NATURE MEDICINE | 2012年 / 18卷 / 01期
关键词：
PROGRESS; MODELS;
D O I：
10.1038/nm.2624
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The search for compounds to treat neurodegenerative disorders is especially pressing given the rapidly growing elderly human population and has led to the consideration of sirtuin proteins as potential therapeutic candidates. Two studies now report that modulating the expression of the sirtuin Sirt1 has therapeutic benefit in Huntington's disease mouse models and identify putative downstream targets of Sirt1 involved in improved disease outcomes (pages 159-165 and 153-158). © 2012 Nature America, Inc. All rights reserved.
引用
收藏
页码：24 / 26
页数：3
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