Modulating the immune system through nanotechnology

被引：90

作者：

Dacoba, Tamara G. ^{[1
,2
]}

Olivera, Ana ^{[1
,2
]}

Torres, Dolores ^{[2
]}

Crecente-Campo, Jose ^{[1
,2
]}

Jose Alonso, Maria ^{[1
,2
]}

机构：

[1] Univ Santiago de Compostela, Ctr Res Mol Med & Chron Dis CIMUS, Campus Vida, Santiago De Compostela 15782, Spain

[2] Univ Santiago de Compostela, Sch Pharm, Dept Pharmacol Pharm & Pharmaceut Technol, Campus Vida, Santiago De Compostela 15782, Spain

来源：

SEMINARS IN IMMUNOLOGY | 2017年 / 34卷 / 0C期

基金：

美国国家卫生研究院; 欧盟地平线“2020”;

关键词：

Nanotechnology; Immune system; Tolerance; Stimulation; Autoimmune disease; Vaccine; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; MYELIN BASIC-PROTEIN; TUMOR-ASSOCIATED MACROPHAGES; ANTIGEN-PRESENTING CELLS; NASAL VACCINE DELIVERY; PEG-PLA NANOPARTICLES; REGULATORY T-CELLS; DENDRITIC CELLS; IN-VIVO; CROSS-PRESENTATION;

D O I：

10.1016/j.smim.2017.09.007

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Nowadays, nanotechnology-based modulation of the immune system is presented as a cutting-edge strategy, which may lead to significant improvements in the treatment of severe diseases. In particular, efforts have been focused on the development of nanotechnology-based vaccines, which could be used for immunization or generation of tolerance. In this review, we highlight how different immune responses can be elicited by tuning nanosystems properties. In addition, we discuss specific formulation approaches designed for the development of anti-infectious and anti-autoimmune vaccines, as well as those intended to prevent the formation of antibodies against biologicals.

引用

页码：78 / 102

页数：25

共 287 条

[1] Lymphatic Targeting of Nanosystems for Anticancer Drug Therapy [J].