Fueling regulation:: IL-2 keeps CD4+ Treg cells fit

被引：104

作者：

Maloy, KJ ^{[1
]}

Powrie, F ^{[1
]}

机构：

[1] Univ Oxford, Sir William Dunn Sch Pathol, Oxford OX1 3RE, England

来源：

NATURE IMMUNOLOGY | 2005年 / 6卷 / 11期

基金：

英国惠康基金;

关键词：

D O I：

10.1038/ni1105-1071

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Naturally occurring regulatory T cells are key in controlling autoimmune and inflammatory responses. New data indicate that although interleukin 2 signals are not essential for regulatory T cell development in the thymus, they are critical for maintenance of these cells in the periphery.

引用

页码：1071 / 1072

页数：2

共 13 条

[1] Homeostasis of peripheral CD4+ T cells:: IL-2Rα and IL-2 shape a population of regulatory cells that controls CD4+ T cell numbers [J].

Almeida, ARM ;

Legrand, N ;

Papiernik, M ;

Freitas, AA .

JOURNAL OF IMMUNOLOGY, 2002, 169 (09) :4850-4860

[2] Development and function of agonist-induced CD25+Foxp3+ regulatory T cells in the absence of interleukin 2 signaling [J].

D'Cruz, LM ;

Klein, L .

NATURE IMMUNOLOGY, 2005, 6 (11) :1152-1159

[3] A function for interleukin 2 in Foxp3-expressing regulatory T cells [J].

Fontenot, JD ;

Rasmussen, JP ;

Gavin, MA ;

Rudensky, AY .

NATURE IMMUNOLOGY, 2005, 6 (11) :1142-1151

[4] Regulatory T cell lineage specification by the forkhead transcription factor FoxP3 [J].

Fontenot, JD ;

Rasmussen, JP ;

Williams, LM ;

Dooley, JL ;

Farr, AG ;

Rudensky, AY .

IMMUNITY, 2005, 22 (03) :329-341

[5] Interleukin 2 signaling is required for CD4+ regulatory T cell function [J].

Furtado, GC ;

de Lafaille, MAC ;

Kutchukhidze, N ;

Lafaille, JJ .

JOURNAL OF EXPERIMENTAL MEDICINE, 2002, 196 (06) :851-857

[6] CD4 regulatory T cells prevent lethal autoimmunity in IL-2Rβ-deficient mice:: implications for the nonredundant function of IL-2 [J].

Malek, TR ;

Yu, AX ;

Vincek, V ;

Scibelli, P ;

Kong, L .

IMMUNITY, 2002, 17 (02) :167-178

[7] Tolerance, not immunity, crucially depends on IL-2 [J].

Malek, TR ;

Bayer, AL .

NATURE REVIEWS IMMUNOLOGY, 2004, 4 (09) :665-674

[8] TGF-β1 maintains suppressor function and Foxp3 expression in CD4+CD25+ regulatory T cells [J].

Marie, JC ;

Letterio, JJ ;

Gavin, M ;

Rudensky, AY .

JOURNAL OF EXPERIMENTAL MEDICINE, 2005, 201 (07) :1061-1067

[9] Regulatory CD4 T cells:: expression of IL-2Rα chain, resistance to clonal deletion and IL-2 dependency [J].

Papiernik, M ;

de Moraes, ML ;

Pontoux, C ;

Vasseur, F ;

Pénit, C .

INTERNATIONAL IMMUNOLOGY, 1998, 10 (04) :371-378

[10] Naturally arising CD4+ regulatory T cells for immunologic self-tolerance and negative control of immune responses [J].

Sakaguchi, S .

ANNUAL REVIEW OF IMMUNOLOGY, 2004, 22 :531-562

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