Hepatoprotective effects of garlic against ethanol-induced liver injury: A mini-review

被引：67

作者：

Guan, Min-Jie ^{[1
]}

Zhao, Ning ^{[1
]}

Xie, Ke-Qin ^{[1
]}

Zeng, Tao ^{[1
]}

机构：

[1] Shandong Univ, Sch Publ Hlth, Inst Toxicol, 44 Wenhua West Rd, Jinan, Shandong, Peoples R China

来源：

FOOD AND CHEMICAL TOXICOLOGY | 2018年 / 111卷

基金：

美国国家科学基金会;

关键词：

Garlic; Alcoholic liver disease; Reactive oxygen species; Nrf-2; Kupffer cells; Adiponectin; INDUCED OXIDATIVE STRESS; ALCOHOLIC FATTY LIVER; INDUCED OXIDANT STRESS; DIALLYL TRISULFIDE; ORGANOSULFUR COMPOUNDS; MOLECULAR-MECHANISMS; CYTOCHROME P4502E1; ADIPONECTIN SECRETION; EXPOSED MICE; RAT-LIVER;

D O I：

10.1016/j.fct.2017.11.059

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Alcoholic liver disease (ALD) is a progressively aggravated liver disease with a diverse spectrum from steatosis to hepatitis, fibrosis, and cirrhosis. Epidemiological studies reveal that alcohol is one of the major causes of advanced liver disease in Europe, United States, and China. Despite the considerable harm, progression in ALD research is slow and the current therapies for ALD have less efficient. Garlic (Allium sativum) has been used as a flavoring agent and also a folk medicine since ancient time. Along with the prosperity in the use of herbal medicines for the treatment of human diseases in recent decades, a series of studies have focused on the beneficial effects of garlic against ALD. This mini-review highlighted the protective roles of garlic against ALD and the potential mechanisms.

引用

页码：467 / 473

页数：7

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