An octameric carbopeptoid; Secondary structure in octameric and tetrameric 5-aminomethyl-tetrahydrofuran-2-carboxylates

被引：78
作者：
Claridge, TDW
Long, DD
Hungerford, NL
Aplin, RT
Smith, MD
Marquess, DG
Fleet, GWJ
机构：
[1] Oxford Ctr Mol Sci, Dyson Perrins Lab, Oxford OX1 3QY, England
[2] Glaxo Wellcome Res & Dev Ltd, Med Res Ctr, Stevenage SG1 2NY, Herts, England
[3] Adv Med Inc, San Francisco, CA 94080 USA
来源：
TETRAHEDRON LETTERS | 1999年 / 40卷 / 11期
关键词：
D O I：
10.1016/S0040-4039(99)00111-2
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The efficient synthesis of an octameric furanose carbopeptoid, readily purified by chromatography in ethyl acetate:hexane (2:1), is reported. Extensive NMR studies suggest that two tetrameric 5-aminomethyltetrahydrofuran-2-carboxylate are prone to adopt solution conformations reminiscent of a repeating beta-turn, a third tetramer and the corresponding octamer may tend towards a left-handed alpha-helix. (C) 1999 Elsevier Science Ltd. All rights reserved.
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收藏
页码：2199 / 2202
页数：4
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