Factors associated with the onset of major depressive disorder in adults with type 2 diabetes living in 12 different countries: results from the INTERPRET-DD prospective study

被引：24

作者：

Lloyd, C. E. ^{[1
]}

Sartorius, N. ^{[2
]}

Ahmed, H. U. ^{[3
]}

Alvarez, A. ^{[4
]}

Bahendeka, S. ^{[5
]}

Bobrov, A. E. ^{[6
]}

Burti, L. ^{[7
]}

Chaturvedi, S. K. ^{[8
]}

Gaebel, W. ^{[9
]}

de Girolamo, G. ^{[10
]}

Gondek, T. M. ^{[11
]}

Guinzbourg, M. ^{[12
]}

Heinze, M. G. ^{[13
]}

Khan, A. ^{[14
]}

Kiejnal, A. ^{[15
,16
]}

Kokoszka, A. ^{[17
]}

Kamala, T. ^{[18
,19
]}

Lalic, N. M. ^{[20
]}

Lecic-Tosevski, D. ^{[21
]}

Mannucci, E. ^{[22
,23
]}

Mankovsku, B. ^{[24
]}

Muessig, K. ^{[25
,26
,27
]}

Mutiso, V ^{[28
]}

Ndetei, D. ^{[29
]}

Nouwen, A. ^{[30
]}

Rabbani, G. ^{[31
]}

Srikanta, S. S. ^{[19
,32
]}

Starostina, E. G. ^{[33
]}

Shevchuk, M. ^{[24
]}

Taj, R. ^{[14
]}

Valentini, U. ^{[34
]}

van Dam, K. ^{[30
]}

Vukovic, O. ^{[35
]}

Wolwer, W. ^{[9
]}

机构：

[1] Open Univ, Milton Keynes, Bucks, England

[2] Assoc Improvement Mental Hlth Programmes, Geneva, Switzerland

[3] Natl Inst Mental Hlth NIMH, Child Adolescent & Family Psychiat, Dhaka, Bangladesh

[4] Hosp Italiano Buenis Aires, Serv Endocrinol & Med Nucl, Buenis Aires, Argentina

[5] Uganda Martyrs Univ, Mother Kevin Post Grad Med Sch, Kampala, Uganda

[6] Fed Med Res Ctr Psychiat & Narcol, Moscow, Russia

[7] Univ Verona, Dept Neurosci Biomed & Movement Sci, Verona, Italy

[8] Natl Inst Mental Hlth & Neurosci, Bangalore, Karnataka, India

[9] Heinrich Heine Univ Dusseldorf, Med Fac, Dept Psychiat & Psychotherapy, Dusseldorf, Germany

[10] Ist Ctr San Giovanni di Dio Fatebenefratelli, Brescia, Italy

[11] European Psychiat Assoc, Early Career Psychiatrists Comm, Wroclaw, Poland

[12] Hosp Italiano Buenos Aires, Serv Psiquiatria, Buenis Aires, Argentina

[13] Univ Nacl Autonoma Mexico, Mexico City, DF, Mexico

[14] Pakistan Inst Med Sci, Islamabad, Pakistan

[15] WSB Univ, Torun, Poland

[16] Univ Lower Silesia, Wroclaw, Poland

[17] Med Univ Warsaw, Dept Psychiat 2, Warsaw, Poland

[18] Diabet Ctr, Bangalore, Karnataka, India

[19] Jnana Sanjeevini Med Ctr, Bangalore, Karnataka, India

[20] Univ Belgrade, Serbian Acad Sci & Arts, Clin Endocrinol, Sch Med, Belgrade, Serbia

[21] Serbian Acad Arts & Sci, Belgrade, Serbia

[22] Diabetol Careggi Teaching Hosp, I-50141 Florence, Italy

[23] Univ Florence, I-50141 Florence, Italy

[24] Natl Med Acad Postgrad Educ, Dept Diabetol, Kiev, Ukraine

[25] Heinrich Heine Univ Dusseldorf, German Diabet Ctr, Leibniz Ctr Diabet Res, Inst Clin Diabetol, Dusseldorf, Germany

[26] Heinrich Heine Univ, Med Fac, Dept Endocrinol & Diabetol, Dusseldorf, Germany

[27] German Ctr Diabet Res DZD, Munich, Germany

[28] Africa Mental Hlth Res & Training Fdn, Nairobi, Kenya

[29] Univ Nairobi, Africa Mental Hlth Res & Training Fdn, Nairobi, Kenya

[30] Middlesex Univ, London, England

[31] Neurodev Protect Trustee Board, Dhaka, Bangladesh

[32] Samatvam Endocrinol Diabet Ctr, Bangalore, Karnataka, India

[33] Moscow Reg Clin & Res Inst, Dept Endocrinol, Moscow, Russia

[34] ASST Spedali Civili, Diabetol Unit, Brescia, Italy

[35] Univ Belgrade, Sch Med, Inst Mental Hlth, Belgrade, Serbia

来源：

EPIDEMIOLOGY AND PSYCHIATRIC SCIENCES | 2020年 / 29卷

关键词：

Depression; mental health; prospective study; psychological assessment; stress; PRIMARY-CARE; RISK-FACTOR; HEALTH; SYMPTOMS; EPIDEMIOLOGY; MORTALITY; ANXIETY; STRESS;

D O I：

10.1017/S2045796020000438

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Aims To examine the factors that are associated with changes in depression in people with type 2 diabetes living in 12 different countries. Methods People with type 2 diabetes treated in out-patient settings aged 18-65 years underwent a psychiatric assessment to diagnose major depressive disorder (MDD) at baseline and follow-up. At both time points, participants completed the Patient Health Questionnaire (PHQ-9), the WHO five-item Well-being scale (WHO-5) and the Problem Areas in Diabetes (PAID) scale which measures diabetes-related distress. A composite stress score (CSS) (the occurrence of stressful life events and their reported degree of 'upset') between baseline and follow-up was calculated. Demographic data and medical record information were collected. Separate regression analyses were conducted with MDD and PHQ-9 scores as the dependent variables. Results In total, there were 7.4% (120) incident cases of MDD with 81.5% (1317) continuing to remain free of a diagnosis of MDD. Univariate analyses demonstrated that those with MDD were more likely to be female, less likely to be physically active, more likely to have diabetes complications at baseline and have higher CSS. Mean scores for the WHO-5, PAID and PHQ-9 were poorer in those with incident MDD compared with those who had never had a diagnosis of MDD. Regression analyses demonstrated that higher PHQ-9, lower WHO-5 scores and greater CSS were significant predictors of incident MDD. Significant predictors of PHQ-9 were baseline PHQ-9 score, WHO-5, PAID and CSS. Conclusion This study demonstrates the importance of psychosocial factors in addition to physiological variables in the development of depressive symptoms and incident MDD in people with type 2 diabetes. Stressful life events, depressive symptoms and diabetes-related distress all play a significant role which has implications for practice. A more holistic approach to care, which recognises the interplay of these psychosocial factors, may help to mitigate their impact on diabetes self-management as well as MDD, thus early screening and treatment for symptoms is recommended.

引用

页数：9

共 38 条

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American Psychiatric Association, 2013, DIAGN STAT MAN MENT, DOI [DOI 10.1176/APPI.BOOKS.9780890425596, 10.1176/appi.books.9780890425596]

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