Economical challenges to microbial producers of butanol: Feedstock, butanol ratio and titer

被引：98

作者：

Gu, Yang ^{[1
]}

Jiang, Yu ^{[1
,2
]}

Wu, Hui ^{[1
]}

Liu, Xudong ^{[1
]}

Li, Zhilin ^{[1
]}

Li, Jian ^{[1
]}

Xiao, Han ^{[1
]}

Shen, Zhaobing ^{[2
]}

Dong, Hongjun ^{[3
]}

Yang, Yunliu ^{[1
]}

Li, Yin ^{[3
]}

Jiang, Weihong ^{[1
,2
]}

Yang, Sheng ^{[1
,2
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Plant Physiol & Ecol, Key Lab Synthet Biol, Shanghai 200032, Peoples R China

[2] Shanghai Res & Dev Ctr Ind Biotechnol, Shanghai, Peoples R China

[3] Chinese Acad Sci, Inst Microbiol, Shanghai 200032, Peoples R China

来源：

BIOTECHNOLOGY JOURNAL | 2011年 / 6卷 / 11期

基金：

中国国家自然科学基金;

关键词：

Butanol; Feedstocks; Metabolic engineering; Ratio; Titer; CLOSTRIDIUM-ACETOBUTYLICUM FERMENTATIONS; SOLVENT-PRODUCING CLOSTRIDIA; JERUSALEM-ARTICHOKE TUBERS; TRANSCRIPTIONAL ANALYSIS; WHEAT-STRAW; ACETONE FORMATION; DOWN-REGULATION; SIMULTANEOUS SACCHARIFICATION; SACCHAROMYCES-CEREVISIAE; CATABOLITE REPRESSION;

D O I：

10.1002/biot.201100046

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Butanol is an important solvent and transport fuel additive, and can be produced by microbial fermentation. Attempts to generate a superior microbial producer of butanol have been made through different metabolic engineering strategies. However, to date, butanol bio-production is still not economically competitive compared to petrochemical-derived production because of its major drawbacks, such as, high cost of the feedstocks, low butanol concentration in the fermentation broth and the co-production of low-value by-products acetone and ethanol. Here we analyze the main bottlenecks in microbial butanol production and summarize relevant advances from recently reported studies. Further needs and directions for developing real industrially applicable strains in butanol production are also discussed.

引用

页码：1348 / 1357

页数：10

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