Cross-modal connectivity effects in age-related hearing loss

被引：8

作者：

Ponticorvo, Sara ^{[1
]}

Manara, Renzo ^{[1
,2
]}

Cassandro, Ettore ^{[1
,3
]}

Canna, Antonietta ^{[4
]}

Scarpa, Alfonso ^{[1
,3
]}

Troisi, Donato ^{[1
,3
]}

Cassandro, Claudia ^{[3
]}

Cuoco, Sofia ^{[1
,3
]}

Cappiello, Arianna ^{[1
,3
]}

Pellecchia, Maria Teresa ^{[1
,3
]}

Di Salle, Francesco ^{[1
,3
]}

Esposito, Fabrizio ^{[4
]}

机构：

[1] Univ Salerno, Dept Med Surg & Dent, Scuola Med Salernitana, Baronissi, Italy

[2] Univ Padua, Dept Neurosci, Padua, Italy

[3] Scuola Med Salernitana, Univ Hosp San Giovanni Dio & Ruggi DAragona, Salerno, Italy

[4] Univ Campania Luigi Vanvitelli, Dept Adv Med & Surg Sci, Piazza Luigi Miraglia 2, I-80138 Naples, Italy

来源：

NEUROBIOLOGY OF AGING | 2022年 / 111卷

关键词：

Hearing loss; Graph theory; Functional connectivity; Structural connectivity; Brain tractography; Visual cortex; STATE FUNCTIONAL CONNECTIVITY; MONTREAL COGNITIVE ASSESSMENT; BRAIN CONNECTOME; AUDITORY-CORTEX; NORMATIVE DATA; DIFFUSION MRI; SMALL-WORLD; ATTENTION; NETWORKS; FMRI;

D O I：

10.1016/j.neurobiolaging.2021.09.024

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Age-related sensorineural hearing loss (HL) leads to localized brain changes in the primary auditory cortex, long-range functional alterations, and is considered a risk factor for dementia. Nonhuman studies have repeatedly highlighted cross-modal brain plasticity in sensorial brain networks other than those primarily involved in the peripheral damage, thus in this study, the possible cortical alterations associated with HL have been analyzed using a whole-brain multimodal connectomic approach. Fifty-two HL and 30 normal hearing participants were examined in a 3T MRI study along with audiological and neurological assessments. Between-regions functional connectivity and whole-brain probabilistic tractography were calculated in a connectome-based manner and graph theory was used to obtain low-dimensional features for the analysis of brain connectivity at global and local levels. The HL condition was associated with a different functional organization of the visual subnetwork as revealed by a significant increase in global efficiency, density, and clustering coefficient. These functional effects were mirrored by similar (but more subtle) structural effects suggesting that a functional repurposing of visual cortical centers occurs to compensate for age-related loss of hearing abilities. (C) 2021 Elsevier Inc. All rights reserved.

引用

页码：1 / 13

页数：13

共 109 条

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