Synthesis and characterization of Schiff bases of aminothiazolylbromo coumarin for their analgesic and anti-inflammatory activity

被引：0
|
作者：
Venugopala, KN [1 ]
Jayashree, BS [1 ]
机构：
[1] Al Ameen Coll Pharm, Dept Pharmaceut Chem, Bangalore 560027, Karnataka, India
来源：
ASIAN JOURNAL OF CHEMISTRY | 2004年 / 16卷 / 01期
关键词：
synthesis; coumarin; thiazole; Schiff bases; analgesic and anti-inflammatory activity;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Some of the Schiff bases of aminothiazolylbromocoumarin are synthesized by the reaction between 2'-amino-4'-(6-bromo-3-coumarinyl) thiazole and substituted aromatic aldehydes. The former is obtained by cyclization of 3-bromoacetyl-6-bromocoumarin and thiourea. The resulting compounds are characterized by spectral data and evaluated for analgesic and anti-inflammatory activity by acetic acid-induced abdominal constriction method and carrageenan induced rat hind paw oedema method respectively. Some of the compounds have shown interesting biological activity based on the presence of certain functional groups.
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页码：407 / 411
页数：5
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