Protective effect of HD-03, a herbal formulation, against various hepatotoxic agents in rats

被引：72
作者：
Mitra, SK [1 ]
Venkataranganna, MV [1 ]
Sundaram, R [1 ]
Gopumadhavan, S [1 ]
机构：
[1] Himalaya Drug Co, R&D Ctr, Bangalore 562123, Karnataka, India
来源：
JOURNAL OF ETHNOPHARMACOLOGY | 1998年 / 63卷 / 03期
关键词：
HD-03; hepatoprotective activity; isoniazid; paracetamol; thioacetamide;
D O I：
10.1016/S0378-8741(98)00088-9
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
HD-03 is a polyherbal formulation containing plant drugs which are known for their hepatoprotective properties in the Ayurvedic system of medicine. In the present study, the formulation was evaluated for its protective effect against diverse hepatotoxic agents viz., paracetamol, thioacetamide and isoniazid. Treatment with HD-03 led to significant amelioration of toxin-induced changes in the biochemical parameters. Since the protective effect of HD-03 was observed in all three types of intoxication, which are different in their primary mechanism of inducing hepatotoxicity, a protective mode of action of HD-03, not specific to the hepatotoxin, is suggested. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.
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收藏
页码：181 / 186
页数：6
相关论文
共 25 条
[1]   ANTIHEPATOTOXIC PROPERTIES OF PICROLIV - AN ACTIVE FRACTION FROM RHIZOMES OF PICRORHIZA-KURROOA [J].
ANSARI, RA ;
TRIPATHI, SC ;
PATNAIK, GK ;
DHAWAN, BN .
JOURNAL OF ETHNOPHARMACOLOGY, 1991, 34 (01) :61-68
[2]   LIVER NECROSIS FROM PARACETAMOL [J].
BOYD, EM ;
BERECZKY, GM .
BRITISH JOURNAL OF PHARMACOLOGY AND CHEMOTHERAPY, 1966, 26 (03) :606-&
[3]  
Chattopadhyay R. R., 1992, Indian Journal of Pharmacology, V24, P163
[4]  
De S., 1993, INDIAN DRUGS, V30, P355
[5]  
DHAWAN B N, 1991, Indian Journal of Pharmacology, V23, P121
[6]   PICROLIV AFFORDS PROTECTION AGAINST THIOACETAMIDE-INDUCED HEPATIC DAMAGE IN RATS [J].
DWIVEDI, Y ;
RASTOGI, R ;
SHARMA, SK ;
GARG, NK ;
DHAWAN, BN .
PLANTA MEDICA, 1991, 57 (01) :25-28
[7]   TISSUE SULFHYDRYL GROUPS [J].
ELLMAN, GL .
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1959, 82 (01) :70-77
[8]  
Gilani A H, 1994, Phytomedicine, V1, P193, DOI 10.1016/S0944-7113(11)80064-4
[9]  
GILANI AH, 1993, MED SCI RES, V21, P151
[10]  
HANDA S S, 1986, Fitoterapia, V57, P307
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