NMR screening and studies of target - ligand interactions

被引：8
|
作者：
Polshakov, Vladimir I. [1 ]
Batuev, Evgeniy A. [2 ]
Mantsyzov, Alexey B. [1 ]
机构：
[1] Lomonosov Moscow State Univ, Fac Fundamental Med, Lab Magnet Tomog & Spect, Lomonosovsky Prosp 27,Stroenie 1, Moscow 119991, Russia
[2] Lomonosov Moscow State Univ, Fac Fundamental Med, Lomonosovsky Prosp 27,Stroenie 1, Moscow 119991, Russia
来源：
RUSSIAN CHEMICAL REVIEWS | 2019年 / 88卷 / 01期
基金：
俄罗斯科学基金会;
关键词：
CASEI DIHYDROFOLATE-REDUCTASE; TRANSFER DIFFERENCE NMR; PARAMAGNETIC RELAXATION ENHANCEMENT; MAPPING STRUCTURAL RELATIONSHIPS; X-RAY CRYSTALLOGRAPHY; DRUG DISCOVERY; STD-NMR; LEAD GENERATION; DNA APTAMER; MEMBRANE-PROTEINS;
D O I：
10.1070/RCR4836
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Nuclear magnetic resonance (NMR) spectroscopy is one of the leading biophysical methods used in the search for and design of physiologically active compounds considered as potential drugs. The review concerns modern NMR techniques used to study the binding of low-molecular-mass compounds to biomacromolecular targets. The most promising methods of NMR screening and strategies for rational lead design are discussed. They were used to design drugs that have been approved for the use in medical practice or are in the final stages of clinical trials. Examples are given of the application of the fragment-based drug design and NMR screening techniques to the design of novel drugs. The bibliography includes 252 references.
引用
收藏
页码：59 / 98
页数：40
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