Skin regeneration in three dimensions, current status, challenges and opportunities

被引：24

作者：

El-Serafi, Ahmed T. ^{[1
,2
,7
]}

El-Serafi, Ibrahim T. ^{[3
,4
,6
]}

Elmasry, Moustafa ^{[5
,6
]}

Steinvall, Ingrid ^{[6
]}

Sjoberg, Folke ^{[6
]}

机构：

[1] Univ Sharjah, Sharjah Inst Med Res, M27-138,POB 27272, Sharjah, U Arab Emirates

[2] Univ Sharjah, Coll Med, M27-138,POB 27272, Sharjah, U Arab Emirates

[3] Karolinska Inst, Dept Lab Med, Div Expt Canc Med, Stockholm, Sweden

[4] Port Said Univ, Fac Med, Port Said, Egypt

[5] Suez Canal Univ, Surg Dept, Plast Surg Unit, Ismailia, Egypt

[6] Linkoping Univ, Burns Ctr, Dept Clin & Expt Med, Dept Hand Surg & Plast Surg & Burns, Linkoping, Sweden

[7] Suez Canal Univ, Fac Med, Ismailia, Egypt

来源：

DIFFERENTIATION | 2017年 / 96卷

关键词：

Skin; Three dimensional; Regeneration; Stem cell; Self-assembly; STEM-CELLS; FIBRIN GLUE; TISSUE; FABRICATION; KERATINOCYTES; CULTURE; MATRICES; FUTURE;

D O I：

10.1016/j.diff.2017.06.002

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Skin regeneration is a life-saving need for many patients, whom list is stretched from burn victims to motor-car accidents. Spraying cells, either keratinocytes or stem cells, were associated with variable results and, in many cases, unfavorable outcomes. As the spatial configuration of the skin is distinctive, many trials investigated the bio-printing or the construction of three dimensional skin models where different layers of the skin were preserved. Although some of these models showed the histological configuration of the skin, their acceptance by the wound was questionable as a consequence of delayed vascularization. In this mini-review, different models for three dimensional regeneration of the skin will be discussed with their main points of strength and challenges as well as their possible opportunities.

引用

页码：26 / 29

页数：4

共 44 条

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