Skeletal rearrangement of arylmethylideneimidazo[4,5-e]thiazolo[3,2-b]-1,2,4-triazine-2,7-diones in the synthesis of the corresponding imidazo[4,5-e]thiazolo[2,3-c]-1,2,4-triazine-2,8-diones

被引：16

作者：

Izmest'ev, Alexei N. ^{[1
]}

Vasileva, Darya A. ^{[1
,2
]}

Melnikova, Elizaveta K. ^{[3
,4
]}

Kolotyrkina, Natalya G. ^{[1
]}

Borisova, Irina A. ^{[1
]}

Kravchenko, Angelina N. ^{[1
]}

Gazieva, Galina A. ^{[1
]}

机构：

[1] Russian Acad Sci, ND Zelinsky Inst Organ Chem, Moscow 119991, Russia

[2] DI Mendeleev Univ Chem Technol Russia, Moscow 125047, Russia

[3] AN Nesmeyanov Inst Organoelement Cpds, Moscow 119991, Russia

[4] Lomonosov Moscow State Univ, Moscow 119991, Russia

来源：

NEW JOURNAL OF CHEMISTRY | 2019年 / 43卷 / 02期

基金：

俄罗斯基础研究基金会;

关键词：

BIOLOGICAL-ACTIVITY; ANTICANCER ACTIVITY; DERIVATIVES; DESIGN; INHIBITORS; DISCOVERY;

D O I：

10.1039/c8nj05058a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Z)-1,3-Dialkyl-7-arylmethylidene-1,3a,4,9a-tetrahydroimidazo[4,5-e]thiazolo[2,3-c]-1,2,4-triazine-2,8(3H,7H)-diones have been prepared via a chemo- and diastereoselective aldol condensation of 1,3-dialkyl-3,3a,9,9a-tetrahydroimidazo[4,5-e]thiazolo[3,2-b]-1,2,4-triazine-2,7(1H,6H)-diones with aromatic aldehydes followed by the skeletal rearrangement of thiazolotriazine fragments. We succeeded in synthesizing hitherto unknown products of alkali-induced skeletal rearrangement of 3a,9a-diphenyl substituted imidazothiazolotriazines.

引用

页码：1038 / 1052

页数：15

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