ALDH enzyme activity is regulated by Nodal and histamine in the A549 cell line

被引：6

作者：

Jiang, Yang ^{[1
]}

Li, Hui ^{[2
]}

Wang, Yi ^{[3
]}

Tian, Tian ^{[3
]}

He, Yan ^{[1
]}

Jin, Yinji ^{[1
]}

Han, Changsong ^{[1
]}

Jin, Xiaoming ^{[1
]}

Zhang, Fengmin ^{[4
]}

Morii, Eiichi ^{[3
]}

机构：

[1] Harbin Med Univ, Dept Pathol, Harbin 150081, Heilongjiang, Peoples R China

[2] Harbin Med Univ, Affiliated Hosp 2, Dept Gastroenterol, Harbin 150086, Heilongjiang, Peoples R China

[3] Osaka Univ, Grad Sch Med, Dept Pathol, 2-2 Yamada Oka, Suita, Osaka 5650871, Japan

[4] Harbin Med Univ, Dept Microbiol, 157 Baojian Rd, Harbin 150081, Heilongjiang, Peoples R China

来源：

ONCOLOGY LETTERS | 2017年 / 14卷 / 06期

关键词：

aldehyde dehydrogenase; nodal; histamine; A549; lung mixed adenocarcinoma; ALDEHYDE DEHYDROGENASE 1; HUMAN EMBRYONIC STEM; EXPRESSION; RECEPTOR; MARKER; CLASSIFICATION; SUPERFAMILY; ACTIVATION; BETA;

D O I：

10.3892/ol.2017.7057

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The present study aimed to examine whether the enzyme activity of aldehyde dehydrogenase (ALDH) was regulated by Nodal and histamine in the human alveolar adenocarcinoma A549 cell line. The regulated enzyme activity of ALDH was analyzed by flow cytometry in the A549 cell line. ALDH1 and Nodal expression was investigated by immunohistochemistry in28 cases of lung mixed adenocarcinoma. The enzyme activity of ALDH was upregulated by histamine and agonists of histamine H1 receptor (H1R) and histamine H2 receptor (H2R). ALDH activity was also downregulated by recombinant human Nodal and antagonists of H1R and H2R in the A549 cell line. In addition, expression of Nodal and ALDH1 were inversely correlated in lung mixed adenocarcinoma. ALDH enzyme activity was regulated by Nodal and histamine in lung adenocarcinoma.

引用

页码：6955 / 6961

页数：7

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