Recent advance in the structural analysis of HIV-1 envelope protein

被引：1

作者：

Matsuda, Zene ^{[1
,2
]}

机构：

[1] Univ Tokyo, Inst Med Sci, Res Ctr Asian Infect Dis, Tokyo 1088639, Japan

[2] Chinese Acad Sci, Inst Biophys, Lab Struct Virol & Immunol, Beijing 100101, Peoples R China

来源：

SCIENCE CHINA-LIFE SCIENCES | 2015年 / 58卷 / 05期

关键词：

HIV-1; envelope glycoprotein; CryoEM; structure; membrane fusion; vaccine; DEPENDENT EPITOPE; MEMBRANE-FUSION; GLYCOPROTEIN; TRIMERS; GP41; ANTIBODIES; INFECTION; GENE; ENV;

D O I：

10.1007/s11427-015-4852-1

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Human immunodeficiency virus type I (HIV-1), a causative agent of AIDS, is affecting today more than 35 millions of people worldwide. The advance of anti-HIV chemotherapy has made AIDS a chronic non-fatal disease in resourceful countries. Long-awaited anti-HIV-1 vaccine is still not with us yet; however, great progress in structural analyses of the envelope protein of HIV-1 in recent years starts to shed light on rational intervention targeted at the envelope protein, as will be reviewed in this article.

引用

页码：420 / 424

页数：5

共 26 条

[1] Structural Delineation of a Quaternary, Cleavage-Dependent Epitope at the gp41-gp120 Interface on Intact HIV-1 Env Trimers [J].

Blattner, Claudia ;

Lee, Jeong Hyun ;

Sliepen, Kwinten ;

Derking, Ronald ;

Falkowska, Emilia ;

de la Pena, Alba Torrents ;

Cupo, Albert ;

Julien, Jean-Philippe ;

van Gils, Marit ;

Lee, Peter S. ;

Peng, Wenjie ;

Paulson, James C. ;

Poignard, Pascal ;

Burton, Dennis R. ;

Moore, John P. ;

Sanders, Rogier W. ;

Wilson, Ian A. ;

Ward, Andrew B. .

IMMUNITY, 2014, 40 (05) :669-680

[2] Three-dimensional solution structure of the 44 kDa ectodomain of SIV gp41 [J].

Caffrey, M ;

Cai, ML ;

Kaufman, J ;

Stahl, SJ ;

Wingfield, PT ;

Covell, DG ;

Gronenborn, AM ;

Clore, GM .

EMBO JOURNAL, 1998, 17 (16) :4572-4584

[3] Core structure of gp41 from the HIV envelope glycoprotein [J].

Chan, DC ;

Fass, D ;

Berger, JM ;

Kim, PS .

CELL, 1997, 89 (02) :263-273

[4] Cell death by pyroptosis drives CD4 T-cell depletion in HIV-1 infection [J].

Doitsh, Gilad ;

Galloway, Nicole L. K. ;

Geng, Xin ;

Yang, Zhiyuan ;

Monroe, Kathryn M. ;

Zepeda, Orlando ;

Hunt, Peter W. ;

Hatano, Hiroyu ;

Sowinski, Stefanie ;

Munoz-Arias, Isa ;

Greene, Warner C. .

NATURE, 2014, 505 (7484) :509-+

[5] Developmental pathway for potent V1V2-directed HIV-neutralizing antibodies [J].

Doria-Rose, Nicole A. ;

Schramm, Chaim A. ;

Gorman, Jason ;

Moore, Penny L. ;

Bhiman, Jinal N. ;

DeKosky, Brandon J. ;

Ernandes, Michael J. ;

Georgiev, Ivelin S. ;

Kim, Helen J. ;

Pancera, Marie ;

Staupe, Ryan P. ;

Altae-Tran, Han R. ;

Bailer, Robert T. ;

Crooks, Ema T. ;

Cupo, Albert ;

Druz, Aliaksandr ;

Garrett, Nigel J. ;

Hoi, Kam H. ;

Kong, Rui ;

Louder, Mark K. ;

Longo, Nancy S. ;

McKee, Krisha ;

Nonyane, Molati ;

O'Dell, Sijy ;

Roark, Ryan S. ;

Rudicell, Rebecca S. ;

Schmidt, Stephen D. ;

Sheward, Daniel J. ;

Soto, Cinque ;

Wibmer, Constantinos Kurt ;

Yang, Yongping ;

Zhang, Zhenhai ;

Mullikin, James C. ;

Binley, James M. ;

Sanders, Rogier W. ;

Wilson, Ian A. ;

Moore, John P. ;

Ward, Andrew B. ;

Georgiou, George ;

Williamson, Carolyn ;

Karim, Salim S. Abdool ;

Morris, Lynn ;

Kwong, Peter D. ;

Shapiro, Lawrence ;

Mascola, John R. .

NATURE, 2014, 509 (7498) :55-+

[6] Cna Menges in HIV vaccine research for treatment and prevention [J].

Ensoli, Barbara ;

Cafaro, Aurelio ;

Monini, Paolo ;

Marcotullio, Simone ;

Ensoli, Fabrizio .

FRONTIERS IN IMMUNOLOGY, 2014, 5

[7] Broadly Neutralizing HIV Antibodies Define a Glycan-Dependent Epitope on the Prefusion Conformation of gp41 on Cleaved Envelope Trimers [J].

Falkowska, Emilia ;

Le, Khoa M. ;

Ramos, Alejandra ;

Doores, Katie J. ;

Lee, Jeong Hyun ;

Blattner, Claudia ;

Ramirez, Alejandro ;

Derking, Ronald ;

van Gils, Marit J. ;

Liang, Chi-Hui ;

Mcbride, Ryan ;

von Bredow, Benjamin ;

Shivatare, Sachin S. ;

Wu, Chung-Yi ;

Chan-Hui, Po-Ying ;

Liu, Yan ;

Feizi, Ten ;

Zwick, Michael B. ;

Koff, Wayne C. ;

Seaman, Michael S. ;

Swiderek, Kristine ;

Moore, John P. ;

Evans, David ;

Paulson, James C. ;

Wong, Chi-Huey ;

Ward, Andrew B. ;

Wilson, Ian A. ;

Sanders, Rogier W. ;

Poignard, Pascal ;

Burton, Dennis R. .

IMMUNITY, 2014, 40 (05) :657-668

[8] Crystal Structure of a Soluble Cleaved HIV-1 Envelope Trimer [J].

Julien, Jean-Philippe ;

Cupo, Albert ;

Sok, Devin ;

Stanfield, Robyn L. ;

Lyumkis, Dmitry ;

Deller, Marc C. ;

Klasse, Per-Johan ;

Burton, Dennis R. ;

Sanders, Rogier W. ;

Moore, John P. ;

Ward, Andrew B. ;

Wilson, Ian A. .

SCIENCE, 2013, 342 (6165) :1477-1483

[9] Lessons from the RV144 Thai Phase III HIV-1 Vaccine Trial and the Search for Correlates of Protection [J].

Kim, Jerome H. ;

Excler, Jean-Louis ;

Michael, Nelson L. .

ANNUAL REVIEW OF MEDICINE, VOL 66, 2015, 66 :423-437

[10] Conformational Changes of the HIV-1 Envelope Protein during Membrane Fusion Are Inhibited by the Replacement of Its Membrane-spanning Domain [J].

Kondo, Naoyuki ;

Miyauchi, Kosuke ;

Meng, Fanxia ;

Iwamoto, Aikichi ;

Matsuda, Zene .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2010, 285 (19) :14681-14688

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