Mathematical models in biology: from molecules to life

被引：3
作者：
Kaznessis, Yiannis N. [1 ]
机构：
[1] Univ Minnesota, Dept Chem Engn & Mat Sci, Minneapolis, MN 55455 USA
来源：
WILEY INTERDISCIPLINARY REVIEWS-SYSTEMS BIOLOGY AND MEDICINE | 2011年 / 3卷 / 03期
基金：
美国国家科学基金会; 美国国家卫生研究院;
关键词：
EXACT STOCHASTIC SIMULATION; COUPLED CHEMICAL-REACTIONS; GENE REGULATORY NETWORKS; COMPUTER-SIMULATIONS; SYSTEMS; DYNAMICS; COMPLEMENT; EQUATIONS; PROTEINS; SYNBIOSS;
D O I：
10.1002/wsbm.142
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
A vexing question in the biological sciences is the following: can biological phenotypes be explained with mathematical models of molecules that interact according to physical laws? At the crux of the matter lies the doubt that humans can develop physically faithful mathematical representations of living organisms. We discuss advantages that synthetic biological systems confer that may help us describe life's distinctiveness with tractable mathematics that are grounded on universal laws of thermodynamics and molecular biology. (C) 2011 John Wiley & Sons, Inc. WIREs Syst Biol Med 2011 3 314-322 DOI: 10.1002/wsbm.142
引用
收藏
页码：314 / 322
页数：9
相关论文
共 58 条
  • [1] Molecular dynamics: Survey of methods for simulating the activity of proteins
    Adcock, Stewart A.
    McCammon, J. Andrew
    [J]. CHEMICAL REVIEWS, 2006, 106 (05) : 1589 - 1615
  • [2] Biological networks: The tinkerer as an engineer
    Alon, U
    [J]. SCIENCE, 2003, 301 (5641) : 1866 - 1867
  • [3] Andrianantoandro E., 2006, Molecular systems biology, V2
  • [4] BECKER OM, 2005, GUIDE BIOMOLECULAR S
  • [5] Antimicrobial mechanism of pore-forming protegrin peptides: 100 pores to kill E. coli
    Bolintineanu, Dan
    Hazrati, Ehsan
    Davis, H. Ted
    Lehrer, Robert I.
    Kaznessis, Yiannis N.
    [J]. PEPTIDES, 2010, 31 (01) : 1 - 8
  • [6] Broglia R.A., 2007, PROTEIN FOLDING DRUG
  • [7] Efficient formulation of the stochastic simulation algorithm for chemically reacting systems
    Cao, Y
    Li, H
    Petzold, L
    [J]. JOURNAL OF CHEMICAL PHYSICS, 2004, 121 (09) : 4059 - 4067
  • [8] Time accelerated Monte Carlo simulations of biological networks using the binomial τ-leap method
    Chatterjee, A
    Mayawala, K
    Edwards, JS
    Vlachos, DG
    [J]. BIOINFORMATICS, 2005, 21 (09) : 2136 - 2137
  • [9] Chipot C., 2007, FREE ENERGY CALCULAT
  • [10] Modeling and simulation of genetic regulatory systems: A literature review
    De Jong, H
    [J]. JOURNAL OF COMPUTATIONAL BIOLOGY, 2002, 9 (01) : 67 - 103
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