Microbial network disturbances in relapsing refractory Crohn's disease

被引：305

作者：

Yilmaz, Bahtiyar ^{[1
,2
]}

Juillerat, Pascal ^{[1
,2
]}

Oyas, Ove ^{[3
,4
]}

Ramon, Charlotte ^{[3
,4
]}

Bravo, Francisco Damian ^{[2
]}

Franc, Yannick ^{[5
]}

Michetti, Pierre ^{[6
]}

Mueller, Christoph ^{[9
]}

Geuking, Markus ^{[1
]}

Pittet, Valerie E. H. ^{[5
]}

Maillard, Michel H. ^{[6
]}

Rogler, Gerhard ^{[10
]}

Abdelrahman, Karim ^{[11
]}

Ademi, Gentiana ^{[12
]}

Aepli, Patrick ^{[13
]}

Thomas, Amman ^{[14
]}

Anderegg, Claudia ^{[15
]}

Antonino, Anca-Teodora ^{[16
]}

Archanioti, Eva ^{[7
,8
]}

Arrigoni, Eviano ^{[17
]}

de Jong, Diana Bakker ^{[18
]}

Balsiger, Bruno ^{[19
]}

Bastuerk, Polat ^{[18
]}

Bauerfeind, Peter ^{[20
]}

Becocci, Andrea ^{[21
]}

Belli, Dominique ^{[21
]}

Bengoa, Jose M. ^{[17
]}

Biedermann, Luc ^{[10
]}

Binek, Janek ^{[22
]}

Blattmann, Mirjam ^{[10
]}

Boehm, Stephan ^{[23
]}

Boldanova, Tujana ^{[24
]}

Borovicka, Jan ^{[12
]}

Braegger, Christian P. ^{[25
]}

Brand, Stephan ^{[12
]}

Brugger, Lukas ^{[2
]}

Brunner, Simon ^{[18
]}

Buehr, Patrick ^{[25
]}

Burnand, Bernard ^{[5
]}

Burk, Sabine ^{[10
]}

Burri, Emanuel ^{[26
]}

Buyse, Sophie ^{[27
]}

Cao, Dahlia-Thao ^{[28
]}

Carstens, Ove ^{[2
]}

Criblez, Dominique H. ^{[13
]}

Cunningham, Sophie ^{[17
]}

D'Angelo, Fabrizia ^{[29
]}

de Saussure, Philippe ^{[17
]}

Degen, Lukas ^{[18
]}

Delarive, Joakim ^{[30
]}

机构：

[1] Univ Bern, Dept Biomed Res, Maurice Muller Labs, Bern, Switzerland

[2] Univ Bern, Univ Hosp Bern, Dept Visceral Surg & Med, Bern, Switzerland

[3] Swiss Fed Inst Technol, Dept Biosyst Sci & Engn, Basel, Switzerland

[4] Swiss Fed Inst Technol, SIB, Basel, Switzerland

[5] Lausanne Univ Hosp, Insti Social & Prevent Med IUMSP, Lausanne, Switzerland

[6] Gastroenterol La Source Beaulieu, Lausanne, Switzerland

[7] CHU Vaudois, Dept Med, Serv Gastroenterol & Hepatol, Lausanne, Switzerland

[8] Univ Lausanne, Lausanne, Switzerland

[9] Univ Bern, Inst Pathol, Div Expt Pathol, Bern, Switzerland

[10] Univ Zurich, Univ Zurich Hosp, Dept Gastroenterol & Hepatol, Zurich, Switzerland

[11] Clin Montchoisi, Lausanne, Switzerland

[12] Kantonsspital St Gallen, St Gallen, Switzerland

[13] Kantonsspital Luzern, Luzern, Switzerland

[14] GI Private Practice, St Gallen, Switzerland

[15] Kantonspital Aarau, Klin Kinder & Jugendliche, Aarau, Switzerland

[16] Hop Riviera Site Samaritain, Vevey, Vaud, Switzerland

[17] GI Private Practice, Geneva, Switzerland

[18] Univ Basel Hosp, Dept Gastroenterol & Hepatol, Basel, Switzerland

[19] Gastroenterolog Praxis, Bern, Switzerland

[20] Stadtspital Triemli, Dept Gastroenterol & Hepatol, Zurich, Switzerland

[21] Geneva Univ Hosp, Dept Pediat, Geneva, Switzerland

[22] Gastroenterol Rosenberg, St Gallen, Switzerland

[23] Spital Bulach, Zurich, Switzerland

[24] Univ Basel, Dept Biomed, Basel, Switzerland

[25] Univ Children Hosp, Zurich, Switzerland

[26] Kantonsspital Liestal, Dept Gastroenterol, Liestal, Switzerland

[27] GI Private Practice, Yverdon Ies Bains, Switzerland

[28] Hosp Neuchatelois, Neuchatel, Switzerland

[29] Geneva Univ Hosp, Dept Gastroenterol & Hepatol, Geneva, Switzerland

[30] GI Private Practice, Lausanne, Switzerland

[31] Clin Cecil, Lausanne, Switzerland

[32] Schulthess Clin, Zurich, Switzerland

[33] GI Private Practice, La Chaux De Fonds, Switzerland

[34] Gastropraxis Luzern, Luzern, Switzerland

[35] Ctr Gastroenterol Beaulieu SA, Geneva, Switzerland

[36] Med Ctr Sihlc, Zurich, Switzerland

[37] Gastroenterol Bethanien, Zurich, Switzerland

[38] Hosp Canton Jura, Jura, Switzerland

[39] UKBB, Basel, Switzerland

[40] Geneva Univ Hosp, Clin Grangettes, Geneva, Switzerland

[41] GI Private Practice, Wettingen, Aargau, Switzerland

[42] Grp Med Onex, Onex, Switzerland

[43] Spital Walenstadt, St Gallen, Switzerland

[44] GI Private Practice, Reinach, Switzerland

[45] Aerztehaus Fluntern, Zurich, Switzerland

[46] GI Private Practice, Olten, Switzerland

[47] HFR Hop Fribourgeois Pediat, Fribourg, Switzerland

[48] KSW Kantonsspital, Winterthur Kinderklin, Winterthur, Switzerland

[49] GI Private Practice, Zurich, Switzerland

[50] GI Private Practice, Luzern, Switzerland

来源：

NATURE MEDICINE | 2019年 / 25卷 / 02期

关键词：

INFLAMMATORY-BOWEL-DISEASE; MUCOSA-ASSOCIATED MICROBIOTA; INVASIVE ESCHERICHIA-COLI; MOLECULAR-PHYLOGENETIC CHARACTERIZATION; TOLL-LIKE RECEPTORS; CD4(+) T-CELLS; GUT MICROBIOTA; ULCERATIVE-COLITIS; FAECALIBACTERIUM-PRAUSNITZII; INTESTINAL INFLAMMATION;

D O I：

10.1038/s41591-018-0308-z

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Inflammatory bowel diseases (IBD) can be broadly divided into Crohn's disease (CD) and ulcerative colitis (UC) from their clinical phenotypes. Over 150 host susceptibility genes have been described, although most overlap between CD, UC and their subtypes, and they do not adequately account for the overall incidence or the highly variable severity of disease. Replicating key findings between two long-term IBD cohorts, we have defined distinct networks of taxa associations within intestinal biopsies of CD and UC patients. Disturbances in an association network containing taxa of the Lachnospiraceae and Ruminococcaceae families, typically producing short chain fatty acids, characterize frequently relapsing disease and poor responses to treatment with anti-TNF-alpha therapeutic antibodies. Alterations of taxa within this network also characterize risk of later disease recurrence of patients in remission after the active inflamed segment of CD has been surgically removed.

引用

页码：323 / +

页数：34

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