Hematopoietic Stem Cell Metabolism during Development and Aging

被引：145
作者：
Nakamura-Ishizu, Ayako [1 ]
Ito, Keisuke [2 ,3 ,4 ,5 ,6 ]
Suda, Toshio [7 ,8 ]
机构：
[1] Tokyo Womens Med Univ, Dept Microscop & Dev Anat, Shinjuku Ku, 8-1 Kawadacho, Tokyo 1628666, Japan
[2] Albert Einstein Coll Med, Ruth L & David S Gottesman Inst Stem Cell & Regen, 1301 Morris Pk Ave, Bronx, NY 10461 USA
[3] Albert Einstein Coll Med, Dept Cell Biol, 1300 Morris Pk Ave, Bronx, NY 10461 USA
[4] Montefiore Med Ctr, Albert Einstein Coll Med, Dept Med Hematooncol, 1300 Morris Pk Ave, Bronx, NY 10461 USA
[5] Albert Einstein Coll Med, Albert Einstein Canc Ctr, 1300 Morris Pk Ave, Bronx, NY USA
[6] Albert Einstein Coll Med, Diabet Res Ctr, 1300 Morris Pk Ave, Bronx, NY USA
[7] Natl Univ Singapore, Canc Sci Inst, 14 Med Dr,MD6, Singapore 117599, Singapore
[8] Kumamoto Univ, Int Res Ctr Med Sci, Chuo Ku, 2-2-1 Honjo, Kumamoto 8600811, Japan
来源：
DEVELOPMENTAL CELL | 2020年 / 54卷 / 02期
基金：
英国医学研究理事会; 美国国家卫生研究院;
关键词：
UMBILICAL-CORD BLOOD; SELF-RENEWAL; BONE-MARROW; MITOCHONDRIAL FISSION; REGULATES QUIESCENCE; RESPIRATORY-CHAIN; ENERGY-METABOLISM; OXIDATIVE STRESS; TRANSGENIC MICE; NITRIC-OXIDE;
D O I：
10.1016/j.devcel.2020.06.029
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Cellular metabolism in hematopoietic stem cells (HSCs) is an area of intense research interest, but the metabolic requirements of HSCs and their adaptations to their niches during development have remained largely unaddressed. Distinctive from other tissue stem cells, HSCs transition through multiple hematopoietic sites during development. This transition requires drastic metabolic shifts, insinuating the capacity of HSCs to meet the physiological demand of hematopoiesis. In this review, we highlight how mitochondrial metabolism determines HSC fate, and especially focus on the links between mitochondria, endoplasmic reticulum (ER), and lysosomes in HSC metabolism.
引用
收藏
页码：239 / 255
页数：17
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