Oxytocin receptor gene (OXTR) is related to psychological resources

被引：203

作者：

Saphire-Bernstein, Shimon ^{[1
]}

Way, Baldwin M. ^{[2
]}

Kim, Heejung S. ^{[3
]}

Sherman, David K. ^{[3
]}

Taylor, Shelley E. ^{[1
]}

机构：

[1] Univ Calif Los Angeles, Dept Psychol, Los Angeles, CA 90095 USA

[2] Ohio State Univ, Dept Psychol, Columbus, OH 43210 USA

[3] Univ Calif Santa Barbara, Dept Psychol, Santa Barbara, CA 93106 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2011年 / 108卷 / 37期

基金：

美国国家科学基金会;

关键词：

LIFE ORIENTATION TEST; LOW SELF-ESTEEM; DEPRESSIVE SYMPTOMS; PSYCHOSOCIAL RESOURCES; DISPOSITIONAL OPTIMISM; STRESS RESPONSES; NEURAL CIRCUITRY; YOUNG ADULTHOOD; HUMANS; HEALTH;

D O I：

10.1073/pnas.1113137108

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Psychological resources-optimism, mastery, and self-esteem-buffer the deleterious effects of stress and are predictors of neurophysiological and psychological health-related outcomes. These resources have been shown to be highly heritable, yet the genetic basis for this heritability remains unknown. Here, we report a link between the oxytocin receptor (OXTR) SNP rs53576 and psychological resources, such that carriers of the "A" allele have lower levels of optimism, mastery, and self-esteem, relative to G/G homozygotes. OXTR was also associated with depressive symptomatology. Mediation analysis indicates that the effects of OXTR on depressive symptoms may be largely mediated by the influence of OXTR on psychological resources.

引用

页码：15118 / 15122

页数：5

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