Neuropathology of dementia in Parkinson's disease: A prospective, community-based study

被引：247
作者：
Aarsland, D
Perry, R
Brown, A
Larsen, JP
Ballard, C
机构：
[1] Stavanger Univ Hosp, N-4068 Stavanger, Norway
[2] Univ Bergen, Sch Med, Bergen, Norway
[3] Newcastle Gen Hosp, Newcastle Upon Tyne NE4 6BE, Tyne & Wear, England
[4] Kings Coll London, London WC2R 2LS, England
来源：
ANNALS OF NEUROLOGY | 2005年 / 58卷 / 05期
关键词：
D O I：
10.1002/ana.20635
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Twenty-two patients with Parkinson's disease drawn from a community-based study were followed prospectively until their deaths. Even though 18 patients had dementia, none fulfilled Braak and Braak or The National Institute on Aging and Ronald and Nancy Reagan Institute of the Alzheimer's Association, whereas all patients had limbic or neocortical Lewy body disease. The Lewy body score and Braak and Braak stage were significantly associated with the rate of cognitive decline, but only the Lewy body score was associated with the rate of cognitive decline in the univariate analyses. This study strongly suggests that Lewy body disease is the main substrate driving the progression of cognitive impairment in Parkinson's disease.
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页码：773 / 776
页数：4
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