Prognostic significance of IDH-1 and MGMT in patients with glioblastoma: One step forward, and one step back?

被引：86

作者：

Combs, Stephanie E. ^{[1
]}

Rieken, Stefan ^{[1
]}

Wick, Wolfgang ^{[2
]}

Abdollahi, Amir ^{[1
]}

von Deimling, Andreas ^{[3
,4
]}

Debus, Juergen ^{[1
]}

Hartmann, Christian ^{[3
,4
]}

机构：

[1] Univ Heidelberg Hosp, Dept Radiat Oncol, Heidelberg, Germany

[2] Univ Heidelberg Hosp, Dept Neurooncol, Heidelberg, Germany

[3] German Canc Res Ctr, Clin Cooperat Unit, D-6900 Heidelberg, Germany

[4] Univ Heidelberg Hosp, Dept Neuropathol, Heidelberg, Germany

来源：

RADIATION ONCOLOGY | 2011年 / 6卷

关键词：

Glioblastoma; radiation; temozolomide; MGMT; IDH; LOMUSTINE PLUS TEMOZOLOMIDE; CODON; 132; MUTATION; BRAIN-TUMORS; O6-METHYLGUANINE-DNA METHYLTRANSFERASE; ADJUVANT TEMOZOLOMIDE; RADIOTHERAPY; GLIOMAS; REPAIR; METHYLATION; CONCOMITANT;

D O I：

10.1186/1748-717X-6-115

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A group of 160 patients with primary glioblastoma treated with radiotherapy and temozolomide was analyzed for the impact of O6-methly-guanly-methyl-transferase (MGMT)-promoter methylation as well as isocitrate dehydrogenase (IDH)1-mutational status. Unexpectedly, overall survival or progression-free survival were not longer in the group with methylated MGMT-promoter as compared to patients without that methylation. IDH-1 mutations were significantly associated with increased overall survival.

引用

页数：5

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