Bioavailability of ginkgolides and bilobalide from extracts of Ginkgo biloba using GC/MS

被引：66

作者：

Biber, A ^{[1
]}

Koch, E ^{[1
]}

机构：

[1] Dr W Schwabe GmbH & Co, Res & Dev, D-76209 Karlsruhe, Germany

来源：

PLANTA MEDICA | 1999年 / 65卷 / 02期

关键词：

D O I：

10.1055/s-2006-960467

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The bioavailability of ginkgolides A, B and bilobalide was studied in rats after single oral administration of 30, 55 and 100 mg/kg Ginkgo extract EGb 761(R). The plasma levels of the terpene lactones were measured by a specific GC/MS method. The pharmacokinetics of the mentioned substances were found to be dose-linear. For the lowest dose maximum concentrations were 68, 40 and 159 ng/ml and half-lives 1.7, 2.0 and 2.2 h for ginkgolide A, B and bilobalide, respectively, Clearance values ranged from 24.2 to 37.6 ml/min/kg.

引用

页码：192 / 193

页数：2