PCSK9 and atherosclerosis: Beyond LDL-cholesterol lowering

被引：17

作者：

Cariou, Bertrand ^{[1
]}

Ding, Zufeng ^{[2
]}

Mehta, Jawahar L. ^{[2
]}

机构：

[1] Univ Nantes, CHU Nantes, INSERM, Inst Thorax,CNRS, Nantes, France

[2] Univ Arkansas Med Sci, Cent Arkansas Vet Helthcare Syst, Little Rock, AR 72205 USA

来源：

ATHEROSCLEROSIS | 2016年 / 253卷

关键词：

PCSK9; Atherosclerosis; Vascular smooth muscle cell; Coronary restenosis; Extra-hepatic; CORONARY-HEART-DISEASE; SMOOTH-MUSCLE-CELLS; LOX-1; ATHEROGENESIS; EXPRESSION; FUTURE; RISK; LONG; MICE;

D O I：

10.1016/j.atherosclerosis.2016.08.007

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

引用

页码：275 / 277

页数：3

共 20 条

[1] Mutations in PCSK9 cause autosomal dominant hypercholesterolemia [J].

Abifadel, M ;

Varret, M ;

Rabès, JP ;

Allard, D ;

Ouguerram, K ;

Devillers, M ;

Cruaud, C ;

Benjannet, S ;

Wickham, L ;

Erlich, D ;

Derré, A ;

Villéger, L ;

Farnier, M ;

Beucler, I ;

Bruckert, E ;

Chambaz, J ;

Chanu, B ;

Lecerf, JM ;

Luc, G ;

Moulin, P ;

Weissenbach, J ;

Prat, A ;

Krempf, M ;

Junien, C ;

Seidah, NG ;

Boileau, C .

NATURE GENETICS, 2003, 34 (02) :154-156

[2] Biomedicine - Lowering LDL - Not only how low, but how long? [J].

Brown, MS ;

Goldstein, JL .

SCIENCE, 2006, 311 (5768) :1721-1723

[3] Role of PCSK9 beyond liver involvement [J].

Cariou, Bertrand ;

Si-Tayeb, Karim ;

Le May, Cedric .

CURRENT OPINION IN LIPIDOLOGY, 2015, 26 (03) :155-161

[4] Clinical aspects of PCSK9 [J].

Cariou, Bertrand ;

Le May, Cedric ;

Costet, Philippe .

ATHEROSCLEROSIS, 2011, 216 (02) :258-265

[5] Sequence variations in PCSK9, low LDL, and protection against coronary heart disease [J].

Cohen, JC ;

Boerwinkle, E ;

Mosley, TH ;

Hobbs, HH .

NEW ENGLAND JOURNAL OF MEDICINE, 2006, 354 (12) :1264-1272

[6]

Ding Z., 2016, ANTIOXID REDOX SIGNA

[7] Cross-talk between LOX-1 and PCSK9 in vascular tissues [J].

Ding, Zufeng ;

Liu, Shijie ;

Wang, Xianwei ;

Deng, Xiaoyan ;

Fan, Yubo ;

Shahanawaz, Jiwani ;

Reis, Robert J. Shmookler ;

Varughese, Kattayi I. ;

Sawamura, Tatsuya ;

Mehta, Jawahar L. .

CARDIOVASCULAR RESEARCH, 2015, 107 (04) :556-567

[8] Hemodynamic Shear Stress via ROS Modulates PCSK9 Expression in Human Vascular Endothelial and Smooth Muscle Cells and Along the Mouse Aorta [J].

Ding, Zufeng ;

Liu, Shijie ;

Wang, Xianwei ;

Deng, Xiaoyan ;

Fan, Yubo ;

Sun, Changqing ;

Wang, Yannian ;

Mehta, Jawahar L. .

ANTIOXIDANTS & REDOX SIGNALING, 2015, 22 (09) :760-771

[9] LOX-1, mtDNA damage, and NLRP3 inflammasome activation in macrophages: implications in atherogenesis [J].

Ding, Zufeng ;

Liu, Shijie ;

Wang, Xianwei ;

Dai, Yao ;

Khaidakov, Magomed ;

Deng, Xiaoyan ;

Fan, Yubo ;

Xiang, David ;

Mehta, Jawahar L. .

CARDIOVASCULAR RESEARCH, 2014, 103 (04) :619-628

[10] Inflammation stimulates the expression of PCSK9 [J].

Feingold, Kenneth R. ;

Moser, Arthur H. ;

Shigenaga, Judy K. ;

Patzek, Sophie M. ;

Grunfeld, Carl .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2008, 374 (02) :341-344

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