CREB: the unindicted cancer co-conspirator

被引：109

作者：

Conkright, MD ^{[1
]}

Montminy, M ^{[1
]}

机构：

[1] Salk Inst Biol Studies, La Jolla, CA 92037 USA

来源：

TRENDS IN CELL BIOLOGY | 2005年 / 15卷 / 09期

关键词：

D O I：

10.1016/j.tcb.2005.07.007

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The transcription factor cAMP response-element binding protein (CREB) participates in a diverse array of cellular processes, including survival, proliferation and glucose metabolism. A new report by Shankar et aL shows that patients with acute myeloid leukemia (AML) have a greater incidence of relapse when intracellular levels of CREB are elevated. By enhancing expression of certain cell-cycle genes, CREB appears to promote growth-factor-independent proliferation and survival of myeloid cells. The results provide new insights into CREB function and suggest potential avenues for therapeutic intervention.

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收藏

页码：457 / 459

页数：3

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