Blockade of cholecystokinin-2 receptor and cyclooxygenase-2 synergistically induces cell apoptosis, and inhibits the proliferation of human gastric cancer cells in vitro

被引：51

作者：

Sun, Wei-Hao ^{[1
]}

Zhu, Feng ^{[2
]}

Chen, Guo-Sheng ^{[1
]}

Su, Han ^{[3
]}

Luo, Cheng ^{[4
,5
]}

Zhao, Qin-Shi ^{[4
]}

Zhang, Yuan ^{[1
]}

Shao, Yun ^{[1
]}

Sun, Jian ^{[6
]}

Zhou, Su-Ming ^{[1
]}

Ding, Guo-Xian ^{[1
]}

Cheng, Yun-Lin ^{[1
]}

机构：

[1] Nanjing Med Univ, Affiliated Hosp 1, Dept Geriatr, Nanjing 210029, Jiangsu, Peoples R China

[2] Shanghai Jiao Tong Univ, Dept Gastroenterol, Shanghai Peoples Hosp 1, Shanghai 200080, Peoples R China

[3] Govt Off Hosp Jiangsu Prov Peoples Govt, Dept Med, Nanjing 210024, Jiangsu, Peoples R China

[4] Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Peoples R China

[5] Univ Turku, Inst Biomed, FIN-20520 Turku, Finland

[6] Univ Hong Kong, Dept Chem, Hong Kong, Hong Kong, Peoples R China

来源：

CANCER LETTERS | 2008年 / 263卷 / 02期

关键词：

cholecystokinin-2; receptor; cyclooxygenase-2; MKN-45; cell; proliferation; apoptosis;

D O I：

10.1016/j.canlet.2008.01.012

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Gastrin and cyclooxygenase-2 (COX-2) play important roles in the carcinogenesis and progression of gastric cancer. However, it remains unknown whether the combination of cholecystokinin-2 (CCK-2) receptor antagonist plus COX-2 inhibitor exerts synergistic anti-tumor effects on human gastric cancer. Here, we demonstrated that the combination of AG-041R (a CCK-2 receptor antagonist) plus NS-398 (a selective COX-2 inhibitor) treatment had synergistic effects on proliferation inhibition, apoptosis induction, down-regulation of Bcl-2 and up-regulation of Bax expression in MKN-45 cells. These results indicate that simultaneous targeting of CCK-2 receptor and COX-2 may inhibit gastric cancer development more effectively than targeting either molecule alone. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

引用

页码：302 / 311

页数：10

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