International Travel as a Risk Factor for Carriage of Extended-Spectrum β-Lactamase-Producing Escherichia coli in a Large Sample of European Individuals-The AWARE Study

被引：11

作者：

Rodriguez-Molina, Daloha ^{[1
,2
,3
,14
]}

Berglund, Fanny ^{[4
,5
]}

Blaak, Hetty ^{[6
]}

Flach, Carl-Fredrik ^{[4
,5
]}

Kemper, Merel ^{[6
]}

Marutescu, Luminita ^{[7
,8
,9
]}

Gradisteanu, Gratiela Pircalabioru ^{[7
,8
,9
]}

Popa, Marcela ^{[7
,8
,9
]}

Spiessberger, Beate ^{[10
,11
,12
]}

Wengenroth, Laura ^{[1
]}

Chifiriuc, Mariana Carmen ^{[7
,8
,9
]}

Larsson, D. G. Joakim ^{[4
,5
]}

Nowak, Dennis ^{[1
,13
]}

Radon, Katja ^{[1
]}

Husman, Ana Maria de Roda ^{[6
]}

Wieser, Andreas ^{[10
,11
,12
]}

Schmitt, Heike ^{[6
]}

机构：

[1] Ludwig Maximilians Univ Munchen, Inst & Clin Occupat Social & Environm Med, Univ Hosp, D-80336 Munich, Germany

[2] Ludwig Maximilians Univ Munchen, Inst Med Informat Proc Biometry & Epidemiol IBE, D-81377 Munich, Germany

[3] Pettenkofer Sch Publ Hlth, D-81377 Munich, Germany

[4] Univ Gothenburg, Sahlgrenska Acad, Inst Biomed, Dept Infect Dis, S-40530 Gothenburg, Sweden

[5] Univ Gothenburg, Ctr Antibiot Resistance Res CARe, S-40530 Gothenburg, Sweden

[6] Natl Inst Publ Hlth & Environm, Ctr Infect Dis Control, NL-3721 MA Bilthoven, Netherlands

[7] Univ Bucharest, Fac Biol, Dept Microbiol & Immunol, Bucharest 050657, Romania

[8] Acad Romanian Scientists, Bucharest 050657, Romania

[9] Univ Bucharest, Res Inst, Earth Environm & Life Sci Sect, Bucharest 030018, Romania

[10] German Ctr Infect Res DZIF, Partner Site Munich, D-80336 Munich, Germany

[11] Ludwig Maximilians Univ Munchen, Max von Pettenkofer Inst, Fac Med, D-81377 Munich, Germany

[12] LMU Univ Hosp Munich, Dept Infect Dis & Trop Med, D-80802 Munich, Germany

[13] German Ctr Lung Res DZL, Comprehens Pneumol Ctr Munich CPC M, D-80336 Munich, Germany

[14] Ludwig Maximilians Univ Munchen, Occupat & Environm Epidemiol & NetTeaching Unit, Inst & Clin Occupat Social & Environm Med, Univ Hosp, Ziemssenstr 5, D-80336 Munich, Germany

来源：

INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH | 2022年 / 19卷 / 08期

基金：

瑞典研究理事会;

关键词：

antibiotic resistance; antimicrobial resistance; risk factors; ESBL E; coli; travels; ANTIBIOTIC-RESISTANCE GENES; ANTIMICROBIAL RESISTANCE; ENTEROBACTERIACEAE; WORKERS; COLONIZATION; EXPOSURE; HEALTH; FARMS;

D O I：

10.3390/ijerph19084758

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Antibiotic resistance (AR) is currently a major threat to global health, calling for a One Health approach to be properly understood, monitored, tackled, and managed. Potential risk factors for AR are often studied in specific high-risk populations, but are still poorly understood in the general population. Our aim was to explore, describe, and characterize potential risk factors for carriage of Extended-Spectrum Beta-Lactamase-resistant Escherichia coli (ESBL-EC) in a large sample of European individuals aged between 16 and 67 years recruited from the general population in Southern Germany, the Netherlands, and Romania. Questionnaire and stool sample collection for this cross-sectional study took place from September 2018 to March 2020. Selected cultures of participants' stool samples were analyzed for detection of ESBL-EC. A total of 1183 participants were included in the analyses: 333 from Germany, 689 from the Netherlands, and 161 from Romania. Travels to Northern Africa (adjusted Odds Ratio, aOR 4.03, 95% Confidence Interval, CI 1.67-9.68), Sub-Saharan Africa (aOR 4.60, 95% CI 1.60-13.26), and Asia (aOR 4.08, 95% CI 1.97-8.43) were identified as independent risk factors for carriage of ESBL-EC. Therefore, travel to these regions should continue to be routinely asked about by clinical practitioners as possible risk factors when considering antibiotic therapy.

引用

页数：19

共 79 条

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[Anonymous], 2018, CLASIFICAREA INT STA

[2]

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