A role for systems epidemiology in tuberculosis research

被引：50

作者：

Comas, Inaki ^{[1
]}

Gagneux, Sebastien ^{[2
,3
]}

机构：

[1] MRC Natl Inst Med Res, Div Mycobacterial Res, London, England

[2] Swiss Trop & Publ Hlth Inst, Dept Med Parasitol & Infect Biol, Basel, Switzerland

[3] Univ Basel, Basel, Switzerland

来源：

TRENDS IN MICROBIOLOGY | 2011年 / 19卷 / 10期

基金：

英国医学研究理事会; 美国国家卫生研究院; 瑞士国家科学基金会;

关键词：

MYCOBACTERIUM-TUBERCULOSIS; LATENT TUBERCULOSIS; GENOMIC DELETIONS; DIVERSITY; EVOLUTION; STRAINS; BIOLOGY; HOST; SUSCEPTIBILITY; PHYLOGEOGRAPHY;

D O I：

10.1016/j.tim.2011.07.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Despite being a curable disease, tuberculosis (TB) killed more people in 2009 than during any previous year in history. Progress in TB research has been slow, and remains burdened by important gaps in our knowledge of the basic biology of Mycobacterium tuberculosis, the causative agent of TB, and its interaction with the human host. Fortunately, major systems biology initiatives have recently been launched that will help fill some of these gaps. However, to fully comprehend TB and control this disease globally, current systems biological approaches will not suffice. The influence of host and pathogen diversity, changes in human demography, and socioeconomic and environmental factors will also need to be considered. Such a multidisciplinary approach might be best described as 'systems epidemiology' in an effort to overcome the traditional boundaries between basic biology and classical epidemiology.

引用

页码：492 / 500

页数：9

共 80 条

[31] Variable host-pathogen compatibility in Mycobacterium tuberculosis [J].

Gagneux, S ;

DeRiemer, K ;

Van, T ;

Kato-Maeda, M ;

de Jong, BC ;

Narayanan, S ;

Nicol, M ;

Niemann, S ;

Kremer, K ;

Gutierrez, MC ;

Hilty, M ;

Hopewell, PC ;

Small, PM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (08) :2869-2873

[32] Global phylogeography of Mycobacterium tuberculosis and implications for tuberculosis product development [J].

Gagneux, Sebastien ;

Small, Peter M. .

LANCET INFECTIOUS DISEASES, 2007, 7 (05) :328-337

[33] Multidrug-resistant and extensively drug-resistant tuberculosis: a threat to global control of tuberculosis [J].

Gandhi, Neel R. ;

Nunn, Paul ;

Dheda, Keertan ;

Schaaf, H. Simon ;

Zignol, Matteo ;

van Soolingen, Dick ;

Jensen, Paul ;

Bayona, Jaime .

LANCET, 2010, 375 (9728) :1830-1843

[34] Whole-Genome Sequencing and Social-Network Analysis of a Tuberculosis Outbreak [J].

Gardy, Jennifer L. ;

Johnston, James C. ;

Sui, Shannan J. Ho ;

Cook, Victoria J. ;

Shah, Lena ;

Brodkin, Elizabeth ;

Rempel, Shirley ;

Moore, Richard ;

Zhao, Yongjun ;

Holt, Robert ;

Varhol, Richard ;

Birol, Inanc ;

Lem, Marcus ;

Sharma, Meenu K. ;

Elwood, Kevin ;

Jones, Steven J. M. ;

Brinkman, Fiona S. L. ;

Brunham, Robert C. ;

Tang, Patrick .

NEW ENGLAND JOURNAL OF MEDICINE, 2011, 364 (08) :730-739

[35] Association of an HLA-DQ allele with clinical tuberculosis [J].

Goldfeld, AE ;

Delgado, JC ;

Thim, S ;

Bozon, MV ;

Uglialoro, AM ;

Turbay, D ;

Cohen, C ;

Yunis, EJ .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1998, 279 (03) :226-228

[36] Allele frequency net: a database and online repository for immune gene frequencies in worldwide populations [J].

Gonzalez-Galarza, Faviel F. ;

Christmas, Stephen ;

Middleton, Derek ;

Jones, Andrew R. .

NUCLEIC ACIDS RESEARCH, 2011, 39 :D913-D919

[37] Single-nucleotide polymorphism-based population genetic analysis of Mycobacterium tuberculosis strains from 4 geographic sites [J].

Gutacker, MM ;

Mathema, B ;

Soini, H ;

Shashkina, E ;

Kreiswirth, BN ;

Graviss, EA ;

Musser, JM .

JOURNAL OF INFECTIOUS DISEASES, 2006, 193 (01) :121-128

[38] ALOX5 variants associated with susceptibility to human pulmonary tuberculosis [J].

Herb, Florian ;

Thye, Thorsten ;

Niemann, Stefan ;

Browne, Edmund N. L. ;

Chinbuah, Margaret A. ;

Gyapong, John ;

Osei, Ivy ;

Owusu-Dabo, Ellis ;

Werz, Oliver ;

Ruesch-Gerdes, Sabine ;

Horstmann, Rolf D. ;

Meyer, Christian G. .

HUMAN MOLECULAR GENETICS, 2008, 17 (07) :1052-1060

[39] High Functional Diversity in Mycobacterium tuberculosis Driven by Genetic Drift and Human Demography [J].

Hershberg, Ruth ;

Lipatov, Mikhail ;

Small, Peter M. ;

Sheffer, Hadar ;

Niemann, Stefan ;

Homolka, Susanne ;

Roach, Jared C. ;

Kremer, Kristin ;

Petrov, Dmitri A. ;

Feldman, Marcus W. ;

Gagneux, Sebastien .

PLOS BIOLOGY, 2008, 6 (12) :2658-2671

[40] Stable association between strains of Mycobacterium tuberculosis and their human host populations [J].

Hirsh, AE ;

Tsolaki, AG ;

DeRiemer, K ;

Feldman, MW ;

Small, PM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (14) :4871-4876

← 1 2 3 4 5 6 7 8 →