A role for systems epidemiology in tuberculosis research

被引：50

作者：

Comas, Inaki ^{[1
]}

Gagneux, Sebastien ^{[2
,3
]}

机构：

[1] MRC Natl Inst Med Res, Div Mycobacterial Res, London, England

[2] Swiss Trop & Publ Hlth Inst, Dept Med Parasitol & Infect Biol, Basel, Switzerland

[3] Univ Basel, Basel, Switzerland

来源：

TRENDS IN MICROBIOLOGY | 2011年 / 19卷 / 10期

基金：

英国医学研究理事会; 美国国家卫生研究院; 瑞士国家科学基金会;

关键词：

MYCOBACTERIUM-TUBERCULOSIS; LATENT TUBERCULOSIS; GENOMIC DELETIONS; DIVERSITY; EVOLUTION; STRAINS; BIOLOGY; HOST; SUSCEPTIBILITY; PHYLOGEOGRAPHY;

D O I：

10.1016/j.tim.2011.07.002

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Despite being a curable disease, tuberculosis (TB) killed more people in 2009 than during any previous year in history. Progress in TB research has been slow, and remains burdened by important gaps in our knowledge of the basic biology of Mycobacterium tuberculosis, the causative agent of TB, and its interaction with the human host. Fortunately, major systems biology initiatives have recently been launched that will help fill some of these gaps. However, to fully comprehend TB and control this disease globally, current systems biological approaches will not suffice. The influence of host and pathogen diversity, changes in human demography, and socioeconomic and environmental factors will also need to be considered. Such a multidisciplinary approach might be best described as 'systems epidemiology' in an effort to overcome the traditional boundaries between basic biology and classical epidemiology.

引用

页码：492 / 500

页数：9

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