A flavonoid gossypin binds to cyclin-dependent kinase 2

被引：16
|
作者：
Kim, Hojung [1 ]
Lee, Eunjung [1 ]
Kim, Jihye [1 ]
Jung, Bora [1 ]
Chong, Youhoon [1 ]
Alm, Joong-Hoon [1 ]
Lim, Yoongho [1 ]
机构：
[1] Konkuk Univ, Dept Biosci & Biotechnol, BMIC, Kwangjin Ku, Seoul 143701, South Korea
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2008年 / 18卷 / 02期
关键词：
cyclin-dependent kinase 2; flavonoids; gossypin; QSAR;
D O I：
10.1016/j.bmcl.2007.11.066
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Flavonoids have low toxicity and mild activity. In order to find flavonoids showing cyclin-dependent kinase 2 (CDK2) binding effects, 347 flavonoid derivatives were docked into the crystal structure of the CDK2. The docking study showed that gossypin has a good conformational match with CDK2, which was confirmed by the binding affinity assay using NMR experiments. (c) 2007 Elsevier Ltd. All rights reserved.
引用
收藏
页码：661 / 664
页数：4
相关论文
共 50 条
  • [41] A simple and efficient docking method to the cyclin-dependent kinase 2
    Park, Kwang-Su
    Kim, Jinyoung
    Chong, Youhoon
    Choo, Hyunah
    BULLETIN OF THE KOREAN CHEMICAL SOCIETY, 2007, 28 (02) : 211 - 219
  • [42] CRYSTAL-STRUCTURE OF CYCLIN-DEPENDENT KINASE-2
    DEBONDT, HL
    ROSENBLATT, J
    JANCARIK, J
    JONES, HD
    MORGAN, DO
    KIM, SH
    NATURE, 1993, 363 (6430) : 595 - 602
  • [43] Cyclin-dependent kinase 2 protects podocytes from apoptosis
    Saurus, Pauliina
    Kuusela, Sara
    Dumont, Vincent
    Lehtonen, Eero
    Fogarty, Christopher L.
    Lassenius, Mariann I.
    Forsblom, Carol
    Lehto, Markku
    Saleem, Moin A.
    Groop, Per-Henrik
    Lehtonen, Sanna
    SCIENTIFIC REPORTS, 2016, 6
  • [44] Cyclins, cyclin-dependent kinases, cyclin-dependent kinase inhibitors and their role in head and neck cancer
    Jeannon, JP
    Wilson, JA
    CLINICAL OTOLARYNGOLOGY, 1998, 23 (05): : 420 - 424
  • [45] Modulation of β-catenin phosphorylation/degradation by cyclin-dependent kinase 2
    Park, CS
    Kim, SI
    Lee, MS
    Youn, CY
    Kim, DJ
    Jho, EH
    Song, WK
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (19) : 19592 - 19599
  • [46] Cyclin-Dependent Kinase 2 Controls Peripheral Immune Tolerance
    Chunder, Neelanjana
    Wang, Liqing
    Chen, Chunxia
    Hancock, Wayne W.
    Wells, Andrew D.
    JOURNAL OF IMMUNOLOGY, 2012, 189 (12): : 5659 - 5666
  • [47] Cyclin-dependent kinase 2 regulates the interaction of Axin with β-catenin
    Kim, SI
    Park, CS
    Lee, MS
    Kwon, MS
    Jho, E
    Song, WK
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2004, 317 (02) : 478 - 483
  • [48] Up-regulation of cyclin-dependent kinase 4/Cyclin d2 expression but down-regulation of cyclin-dependent kinase 2/cyclin E in testicular germ cell tumors
    Schmidt, BA
    Rose, A
    Steinhoff, C
    Strohmeyer, T
    Hartmann, M
    Ackermann, R
    CANCER RESEARCH, 2001, 61 (10) : 4214 - 4221
  • [49] Cyclin-dependent kinase 2 nucleocytoplasmic translocation is regulated by extracellular regulated kinase
    Keenan, SM
    Bellone, C
    Baldassare, JJ
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (25) : 22404 - 22409
  • [50] Cyclin-dependent kinase inhibitors for treating cancer
    Toogood, PL
    MEDICINAL RESEARCH REVIEWS, 2001, 21 (06) : 487 - 498
12345