A flavonoid gossypin binds to cyclin-dependent kinase 2

被引：16

作者：

Kim, Hojung ^{[1
]}

Lee, Eunjung ^{[1
]}

Kim, Jihye ^{[1
]}

Jung, Bora ^{[1
]}

Chong, Youhoon ^{[1
]}

Alm, Joong-Hoon ^{[1
]}

Lim, Yoongho ^{[1
]}

机构：

[1] Konkuk Univ, Dept Biosci & Biotechnol, BMIC, Kwangjin Ku, Seoul 143701, South Korea

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2008年 / 18卷 / 02期

关键词：

cyclin-dependent kinase 2; flavonoids; gossypin; QSAR;

D O I：

10.1016/j.bmcl.2007.11.066

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Flavonoids have low toxicity and mild activity. In order to find flavonoids showing cyclin-dependent kinase 2 (CDK2) binding effects, 347 flavonoid derivatives were docked into the crystal structure of the CDK2. The docking study showed that gossypin has a good conformational match with CDK2, which was confirmed by the binding affinity assay using NMR experiments. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：661 / 664

页数：4

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