A flavonoid gossypin binds to cyclin-dependent kinase 2

被引：16
|
作者：
Kim, Hojung [1 ]
Lee, Eunjung [1 ]
Kim, Jihye [1 ]
Jung, Bora [1 ]
Chong, Youhoon [1 ]
Alm, Joong-Hoon [1 ]
Lim, Yoongho [1 ]
机构：
[1] Konkuk Univ, Dept Biosci & Biotechnol, BMIC, Kwangjin Ku, Seoul 143701, South Korea
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2008年 / 18卷 / 02期
关键词：
cyclin-dependent kinase 2; flavonoids; gossypin; QSAR;
D O I：
10.1016/j.bmcl.2007.11.066
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Flavonoids have low toxicity and mild activity. In order to find flavonoids showing cyclin-dependent kinase 2 (CDK2) binding effects, 347 flavonoid derivatives were docked into the crystal structure of the CDK2. The docking study showed that gossypin has a good conformational match with CDK2, which was confirmed by the binding affinity assay using NMR experiments. (c) 2007 Elsevier Ltd. All rights reserved.
引用
收藏
页码：661 / 664
页数：4
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