Concentrations of Tenofovir and Emtricitabine in Breast Milk of HIV-1-Infected Women in Abidjan, Cote d'Ivoire, in the ANRS 12109 TEmAA Study, Step 2

被引：112

作者：

Benaboud, Sihem ^{[1
,2
]}

Pruvost, Alain ^{[3
]}

Coffie, Patrick A.

Ekouevi, Didier K.

Urien, Saik ^{[1
,2
]}

Arrive, Elise ^{[4
]}

Blanche, Stephane ^{[5
]}

Theodoro, Frederic ^{[3
]}

Avit, Divine

Dabis, Francois ^{[4
]}

Treluyer, Jean-Marc ^{[1
,2
]}

Hirt, Deborah ^{[1
]}

机构：

[1] Hop Cochin, AP HP, CIC Inserm 0901, F-75674 Paris, France

[2] Univ Paris 05, EA 3620, Paris, France

[3] CEA, IBiTecS, SPI, Lab Etud Metab Medicaments, F-91191 Gif Sur Yvette, France

[4] Univ Victor Segalen, ISPED, INSERM, Equipe VIH Int,U593, Bordeaux, France

[5] Hop Necker Enfants Malad, AP HP, Serv Immunol Pediat, Paris, France

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2011年 / 55卷 / 03期

关键词：

NEVIRAPINE; SINGLE; PHARMACOKINETICS; RESISTANCE;

D O I：

10.1128/AAC.00514-10

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The aim was to evaluate emtricitabine (FTC) and tenofovir (TFV) neonatal ingestion through breast milk. Median TFV and FTC breast milk doses represented 0.03% and 2%, respectively, of the proposed oral infant doses. Neonatal simulated plasma concentrations were extremely low for TFV but between the half-maximal inhibitory concentration and the adult minimal expected concentration for FTC. The rare children who will acquire HIV despite TDF-FTC therapy will need to be monitored for viral resistance acquisition.

引用

页码：1315 / 1317

页数：3

共 14 条

[1]

[Anonymous], RAP ADV REV WHO PRIN

[2]

[Anonymous], RAP ADV US ANT DRUGS

[3] Prevalence of resistance to nevirapine in mothers and children after single-dose exposure to prevent vertical transmission of HIV-1:: a meta-analysis [J].

Arrive, Elise ;

Newell, Marie-Louise ;

Ekouevi, Didier K. ;

Chaix, Marie-Laure ;

Thiebaut, Rodolphe ;

Masquelier, Bernard ;

Leroy, Valeriane ;

Van de Perre, Philippe ;

Rouzioux, Christine ;

Dabis, Francois .

INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 2007, 36 (05) :1009-1021

[4] Single-dose tenofovir and emtricitabine for reduction of viral resistance to non-nucleoside reverse transcriptase inhibitor drugs in women given intrapartum nevirapine for perinatal HIV prevention: an open-label randomised trial [J].

Chi, Benjamin H. ;

Sinkala, Moses ;

Mbewe, Felistas ;

Cantrell, Ronald A. ;

Kruse, Gina ;

Chintu, Namwinga ;

Aldrovandi, Grace M. ;

Stringer, Elizabeth M. ;

Kankasa, Chipepo ;

Safrit, Jeffrey T. ;

Stringer, Jeffrey S. A. .

LANCET, 2007, 370 (9600) :1698-1705

[5]

*GIL SCI INC, 2003, VIR TEN DIS FUM TABL

[6] Population Pharmacokinetics of Tenofovir in HIV-1-Infected Pregnant Women and Their Neonates (ANRS 12109) [J].

Hirt, D. ;

Urien, S. ;

Ekouevi, D. K. ;

Rey, E. ;

Arrive, E. ;

Blanche, S. ;

Amani-Bosse, C. ;

Nerrienet, E. ;

Gray, G. ;

Kone, M. ;

Leang, S. K. ;

McIntyre, J. ;

Dabis, F. ;

Treluyer, J-M .

CLINICAL PHARMACOLOGY & THERAPEUTICS, 2009, 85 (02) :182-189

[7] Population Pharmacokinetics of Emtricitabine in Human Immunodeficiency Virus Type 1-Infected Pregnant Women and Their Neonates [J].

Hirt, Deborah ;

Urien, Saik ;

Rey, Elisabeth ;

Arrive, Elise ;

Ekouevi, Didier K. ;

Coffie, Patrick ;

Leang, Sim Kruy ;

Lalsab, Sarita ;

Avit, Divine ;

Nerrienet, Eric ;

McIntyre, James ;

Blanche, Stephane ;

Dabis, Francois ;

Treluyer, Jean-Marc .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2009, 53 (03) :1067-1073

[8]

Lidstrom J, 2010, 17 C RETR OPP INF SA

[9] Response to antiretroviral therapy after a single, peripartum dose of nevirapine [J].

Lockman, Shahin ;

Shapiro, Roger L. ;

Smeaton, Laura M. ;

Wester, Carolyn ;

Thior, Ibou ;

Stevens, Lisa ;

Chand, Fatima ;

Makhema, Joseph ;

Moffat, Claire ;

Asmelash, Aida ;

Ndase, Patrick ;

Arimi, Peter ;

van Widenfelt, Erik ;

Mazhani, Loeto ;

Novitsky, Vladimir ;

Lagakos, Stephen ;

Essex, Max .

NEW ENGLAND JOURNAL OF MEDICINE, 2007, 356 (02) :135-147

[10] Antiretroviral Concentrations in Breast-Feeding Infants of Mothers Receiving Highly Active Antiretroviral Therapy [J].

Mirochnick, Mark ;

Thomas, Timothy ;

Capparelli, Edmund ;

Zeh, Clement ;

Holland, Diane ;

Masaba, Rose ;

Odhiambo, Prisca ;

Fowler, Mary Glenn ;

Weidle, Paul J. ;

Thigpen, Michael C. .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2009, 53 (03) :1170-1176

← 1 2 →