"One-Pot" Selective Synthesis of 3,4-Disubstituted Pyrroles and Benzo[f]indole-4,9-diones from 1,3-Indanedione, Aromatic Aldehydes and TosMIC

被引：19
作者：
Aitha, Anjaiah [1 ,2 ]
Payili, Nagaraju [1 ]
Rekula, Santhosh Reddy [1 ]
Yennam, Satyanarayana [1 ]
Anireddy, Jaya Shree [2 ]
机构：
[1] GVK Biosci Pvt Ltd, Dept Med Chem, Chem Serv, IDA Mallapur, Survey 125 Part & 126, Hyderabad 500076, Telangana, India
[2] Jawaharlal Nehru Technol Univ, Inst Sci & Technol, Ctr Chem Sci & Technol, Hyderabad 500072, Telangana, India
来源：
CHEMISTRYSELECT | 2017年 / 2卷 / 24期
关键词：
cycloaddition; pyrroles; ring cleavage; ring expansion; tandem; SULFONYLMETHYL ISOCYANIDES; CYCLOADDITION REACTION; SUBSTITUTED PYRROLES; REGIOSELECTIVE SYNTHESIS; DERIVATIVES; CHEMISTRY; HYBRIDS; ALKYNES; DESIGN; ACCESS;
D O I：
10.1002/slct.201700997
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A variety of 3,4-disubstituted pyrroles and benzo[f]indole-4,9-diones have been selectively synthesized from readily available aromatic aldehydes, 1,3-Indanedione and tosylmethyl isocyanide (TosMIC) by a one-pot procedure in high yields. This methodology features operationally simple, practical with broad substrate scope and usage of easy to handle reagents. The one-pot sequential reactions proposed to proceeds through a tandem insitu generated chalcones and [3 + 2]-cycloaddition/ring cleavage or expansion process.
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收藏
页码：7246 / 7250
页数：5
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